Last update 08 May 2025

Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
CCND1 x CDK4 x CDK6
Action
inhibitors
Mechanism
CCND1 inhibitors(Cyclin D1 inhibitors), CDK4 inhibitors(Cyclin-dependent kinase 4 inhibitors), CDK6 inhibitors(Cyclin-dependent kinase 6 inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Neoplasms
Inactive Indication-
Originator Organization
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount SinaiCullgen, Inc.Cullgen, Inc.
Active Organization
Cullgen, Inc.Cullgen, Inc.
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC52H65N11O7S
InChIKeyYEWRCNAQUTTYAY-ODJFMHKTSA-N
CAS Registry-

Related

100 Clinical Results associated with Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)
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100 Translational Medicine associated with Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)
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100 Patents (Medical) associated with Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)
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1
Literatures (Medical) associated with Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)
14 Dec 2022Journal of the American Chemical Society
Bridged Proteolysis Targeting Chimera (PROTAC) Enables Degradation of Undruggable Targets
100 Deals associated with Bridged PROTAC Cpd 4(Icahn School of Medicine at Mount Sinai)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPreclinical
United States
Cullgen, Inc.Cullgen, Inc.
30 Nov 2022
NeoplasmsPreclinical
United States
Icahn School of Medicine at Mount SinaiIcahn School of Medicine at Mount Sinai
30 Nov 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Approval

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Regulation

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