Targeted cytotoxicity against MDA-MB- 231 triple-negative breast cancer cells with Borassus flabellifer haustorium-derived silver nanoparticles: An integrated in silico and experimental approach

Author: Haja Mohaideen, Noorul SamsoonMaharifa ; Srinivasan, Hemalatha ; Jenin Ravindranath, Karunya

TNBC, Triple-neg breast cancer is a challenging threat, particularly affecting young women who continue to lack effective treatments.In spite of missing typical surface receptors like ER, PR, and HER2, recent research hints at the possible emergence of hormonal receptors ER, EGFR, and CD44 in TNBC cells.Exploiting this insight, Borassus flabellifer haustorium-derived phytocompounds were screened in silico, revealing efficient targeting of hormonal receptors.Subsequent in-vitro work employed, silver nanoparticles synthesized from Borassus flabellifer haustorium (BFHNPs), characterized through UV-Vis Spectrophotometer, FTIR, DLS, and Zeta Potentiometer.These nanoparticles exhibited cytotoxicity against MDA-MB- 231 cell lines, presenting a promising therapeutic avenue for TNBC, potentially addressing its aggressive nature and unmet medical need.

05 Apr 2023·Journal of the American Chemical Society

Total Synthesis of Strempeliopidine and Non-Natural Stereoisomers through a Convergent Petasis Borono-Mannich Reaction.

Article

Author: Rand, Alexander W. ; Virgil, Scott C. ; Stoltz, Brian M. ; Reimann, Christopher E. ; Gonzalez, Kevin J.

Strempeliopidine is a member of the monoterpenoid bisindole alkaloid family, a class of natural products that have been shown to elicit an array of biological responses including modulating protein-protein interactions in human cancer cells. Our synthesis of strempeliopidine leverages palladium-catalyzed decarboxylative asymmetric allylic alkylations to install the requisite all-carbon quaternary centers found in each of the two monomeric natural products, aspidospermidine and eburnamine. Initial studies employing Suzuki-Miyaura cross-coupling followed by diastereoselective hydrogenation provided evidence for a structural reassignment of the natural product. Our final synthetic sequence employs a diastereoselective Petasis borono-Mannich reaction to couple eburnamine to a trifluoroborate aspidospermidine derivative. These convergent approaches enabled the synthesis of eight diastereomers of this heterodimer and offer support for the reassignment of the absolute configuration of strempeliopidine.

01 Sep 2022·Chemistry – A European Journal

Superacid‐Mediated Late‐Stage Aromatic Polydeuteration of Pharmaceuticals

Article

Author: Appert, Emeline ; Martin‐Mingot, Agnès ; Thibaudeau, Sébastien ; Michelet, Bastien ; Bouazza, Fodil ; Zunino, Fabien ; Karam, Omar

AbstractThe field of medicinal chemistry is currently witnessing a deuterium rush owing to the remarkable properties of this element as bioisoster of hydrogen atom. Aromatic hydrogen isotope exchange (HIE) is one of the most studied strategies nowadays as it promises to access deuterium‐modified drugs directly from their non‐labeled parents. While most of the recent studies focus on metal‐catalyzed C−H activation strategy, the use of superacidic conditions has been largely overlooked. This study shows that the use of TfOD as reaction medium allows the late‐stage polydeuteration of a broad library of pharmaceuticals bearing a wide array of functional groups, complementing existing procedures.

100 Deals associated with Vinburnine

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KEGG	Wiki	ATC	Drug Bank
D08676	Vinburnine	C04AX17	DB13793

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