100 Clinical Results associated with Recombinant human granulocyte/macrophage colony-stimulating factor(Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.)

100 Translational Medicine associated with Recombinant human granulocyte/macrophage colony-stimulating factor(Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.)

100 Patents (Medical) associated with Recombinant human granulocyte/macrophage colony-stimulating factor(Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.)

Literatures (Medical) associated with Recombinant human granulocyte/macrophage colony-stimulating factor(Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.)

01 Sep 2010·The Journal of Pharmacology and Experimental TherapeuticsQ3 · MEDICINE

Impaired Function of Dendritic Cells Deficient in Angiotensin II Type 1 Receptors

Q3 · MEDICINE

Article

Author: Schultheiss, Heinz-Peter ; Uharek, Lutz ; Walther, Thomas ; Wang, Yong ; Vermeulen, Monica ; Nahmod, Karen ; Gentilini, Ciara ; Geffner, Jorge ; Zhang, Jialin

Dendritic cells (DC) are highly specialized antigen-presenting cells with a unique ability to activate resting T lymphocytes and initiate primary immune responses. Angiotensin II (AII) is involved in key events of the inflammatory response. Because our previous work implicated an effect of AII on differentiation and function of murine and human DC, we investigated the impact of AII type 1 receptor (AT(1)) deficiency on the phenotypical and functional properties of mouse DC in vitro and in vivo. Bone marrow (BM) cells isolated from mice lacking AII subtype 1a receptor (AT(1a)), AII subtype 1b receptor (AT(1b)), or both receptor isoforms and control littermates [wild type (WT)] were cultured for 7 days in the presence of recombinant mouse granulocyte/macrophage colony-stimulating factor to generate myeloid DC in vitro. Generation of CD11c(+) cells was less efficient in both AT(1a)- and AT(1b)-deficient BM cells than in WT BM cell cultures. Moreover, DC generated from AT(1)-deficient progenitors showed lower levels of expression of major histocompatibility complex II (MHC-II) and CD11c (p < 0.01) and a marked reduction in their allostimulatory activity (p < 0.01 or 0.001). Although AT(1)-deficient DC released comparable levels of interleukin (IL)-10 and IL-12p70 to WT DC, they produced significantly lower levels of tumor necrosis factor alpha (TNF-alpha) (p < 0.05). Remarkably, CD11c(+) cells isolated from the spleen of AT(1) knockout mice challenged with lipopolysaccharide in vivo up-regulated MHC-II, CD40, and CD80 as did WT, but released significantly lower levels of TNF-alpha (p < 0.01). These data provide clear evidence that AT(1) controls differentiation and functionality of DC and thus may have a crucial impact on inflammatory processes where local angiotensinergic systems are known to be activated.

01 Jan 2001·Journal of Investigative SurgeryQ4 · MEDICINE

Effect of Recombinant Human Granulocyte/Macrophage Colony-Stimulating Factor on the Healing of Colonic Anastomosis in Rats

Q4 · MEDICINE

Article

Author: Neriman Sengül ; Cihan Bumin ; Aydin Inan ; Seher Demirer ; Ercüment Kuterdem ; Aydan Eroglu

The purpose of this study was to investigate the efficacy of recombinant human granulocyte/macrophage colony-stimulating factor (rHuGM-CSF) on the wound healing of colonic anastomosis in rats. In total, 40 male Wistar rats were taken into this study. The control group (n = 20) received subcutaneous saline injection. The experiment group (n = 20) received rHuGM-CSF at 100 microg/kg subcutaneously. Both groups underwent colonic anastomosis 2 days later. In each group, burst pressure and hydroxyproline levels were determined 3 and 7 days after anastomosis. White blood cell (WBC) and red blood cell (RBC) counts were determined in each group to evaluate the effect of rHuGM-CSF on hematologic parameters in rats. There was no significant difference between the two groups in regard to burst pressure and hydroxyproline levels (p > .05). As expected, WBC counts significantly increased in the experiment group on days 3 (p = .035) and 7 (p = .046) following surgery. In conclusion, rHuGM-CSF administration and increased WBC counts did not have any positive effect on the wound healing of colonic anastomosis.

01 Jun 1995·European Journal of ImmunologyQ3 · MEDICINE

Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation

Q3 · MEDICINE

Article

Author: Christoph Scheicher ; Konrad Reske ; Maria Mehlig ; Hans-Peter Dienes

AbstractDendritic cells synthesize and express major histocompatibility complex (MHC) class II peptide‐binding elements constitutively and, therefore, belong to the category of professional antigen‐presenting cells. Unlike other cells that show constitutive class II expression, such as B cells and certain T cell clones, dendritic cells possess the unique capacity to activate naive T cells. Using dendritic cells generated in vitro by culture of mouse bone marrow in the presence of low doses of recombinant mouse granulocyte/macrophage colony‐stimulating factor, we found that discrete maturation stages of these cells can be distinguished which were correlated with defined functional capabilities. The striking observation was the presence of a progenitor dendritic cell expressing low levels of class II which, unlike its differentiated counterpart in vitro, possessed pronounced phagocytic activity. Adding protein antigen to dendritic cells in a particle‐adsorbed form, as compared to a soluble form, we demonstrate that phagocytosis of the particle‐adsorbed protein by progenitor dendritic cells involves an activation event. This is evidenced by the de novo synthesis of transcripts of interleukin‐1α and interleukin‐12 p40/p35 as well as transcripts of MHC class II. Most importantly, an augmented and prolonged antigen‐presentation capacity was observed when the antigen was given in particle‐adsorbed instead of soluble form. These findings indicate that progenitor dendritic cells are functionally more flexible and potent than fully differentiated dendritic cells and that they play a crucial role in antigen presentation. It is suggested that these findings will open up new possibilities to devise strategies for vaccine development.

100 Deals associated with Recombinant human granulocyte/macrophage colony-stimulating factor(Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd.)

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	L03AA02	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Leukopenia	China	Guangzhou Baiyunshan Bai Di Bio-technology Co., Ltd.	10 Oct 2005
Myelodysplastic Syndromes	China	Guangzhou Baiyunshan Bai Di Bio-technology Co., Ltd.	10 Oct 2005

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis