Delving into the Latest Updates on Para-Toluenesulfonamide with Synapse

We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols with estrogenic activity (i.e. phytoestrogens). We identified that phytoestrogens target genes linked to disrupted cellular homeostasis, e.g. genes limiting DNA break repair (RNF169) or promoting ribosomal biogenesis (rDNA). Existing evidence suggests that DNA methylation may be governed by sirtuin 1 (SIRT1) deacetylase via interactions with DNA methylating enzymes, specifically DNMT3B. Since SIRT1 was reported to be regulated by phytoestrogens, we test whether phytoestrogens suppress genes related to disrupted homeostasis via SIRT1/DNMT3B-mediated transcriptional silencing. Human MCF10A mammary epithelial cells were treated with phytoestrogens, pterostilbene (PTS) or genistein (GEN), followed by analysis of cell growth, DNA methylation, gene expression, and SIRT1/DNMT3B binding. SIRT1 occupancy at the selected phytoestrogen-target genes, RNF169 and rDNA, was accompanied by consistent promoter hypermethylation and gene downregulation in response to GEN, but not PTS. GEN-mediated hypermethylation and SIRT1 binding were linked to a robust DNMT3B enrichment at RNF169 and rDNA promoters. This was not observed in cells exposed to PTS, suggesting a distinct mechanism of action. Although both SIRT1 and DNMT3B bind to RNF169 and rDNA promoters upon GEN, the two proteins do not co-occupy the regions. Depletion of SIRT1 abolishes GEN-mediated decrease in rDNA expression, suggesting SIRT1-dependent epigenetic suppression of rDNA by GEN. These findings enhance our understanding of the role of SIRT1-DNMT3B interplay in epigenetic mechanisms mediating the impact of phytoestrogens on cell biology and cellular homeostasis.

01 Jul 2025·Journal of Colloid and Interface Science

In situ doping Pt single atoms into 3D flower-like 1T-MoS2 via Pt-S bond for efficient hydrogen evolution reaction

Article

Author: Li, Ziya ; Zhuang, Tao ; Lv, Zhiguo ; Zhang, Delu ; Wang, Haipeng ; Zhang, Chao

Combining single atoms via phase transition engineering (from 2H to 1T) remains a challenge in MoS₂-based catalysts. Herein, we report that Pt single atoms (Pt_SA) were doped into a 3D flower-like 1T-MoS₂ catalyst (Pt_SA@MoS₂) using a Pt-S bonding strategy. Doping with Pt_SA induced a phase transition in MoS₂ from the 2H phase to the 1T phase. Pt_SA@MoS₂ exhibited outstanding hydrogen evolution reaction (HER) performance, featuring an overpotential of 25 mV at 10 mA cm^-2, a Tafel slope of 43.6 mV dec^-1, and excellent long-term stability. The Pt-S first-shell scattering of Pt_SA@MoS₂ in extended X-ray absorption fine structure (EXAFS) directly indicated that the Pt_SA was anchored near S atoms, forming Pt-S bonds. Furthermore, S atoms proximal to Pt functioned as catalytically active sites for HER, with Pt acting as an electron transfer mediator, facilitating the electron transfer from Mo to Pt and then to S. The p-band center of S showed a positive shift, indicating that Pt_SA@MoS₂ interacted weakly with hydrogen, thereby accelerating the desorption of H atoms to generate H₂. Additionally, Pt_SA@MoS₂ exhibited a ΔG_H* of only -0.13 eV, which also favored H₂ production.

01 Jul 2025·Journal of Hazardous Materials

Phenyltins may pose a higher health risk to Indo-Pacific finless porpoises than butyltins

Article

Author: Wu, Yuping ; Xie, Yanqing ; Liang, Zhenrui ; Yu, Ronglan ; Liu, Fei ; Sun, Qinzhe ; Xie, Zhenhui ; Zhang, Xiyang

Organotin (OT) compounds are commonly used in antifouling paints, but can cause toxic effects in various marine organisms, including gastropods, amphibians, and teleosts. The effects of these chemicals on marine mammals remain largely unknown. We comprehensively investigated the accumulation patterns and health risks of six OTs in Indo-Pacific finless porpoises (Neophocaena phocaenoides) from the Pearl River Estuary (PRE), China, from 2007 to 2020. Six OTs were detected in all the finless porpoise samples, with tributyltin (TPT) and dibutyltin (DBT) being the dominant chemicals in the liver and muscle, respectively. The mean hepatic concentration of TPT (516.1 ng g^-1 wet weight) exceeded the levels reported for cetaceans from other regions. Despite the observed decreasing trends of butyltins (BTs) in recent years, which aligns with the global restriction of OT-based antifouling paints since 2008, phenyltins (PTs) have continued to increase in porpoise tissues, suggesting continued deposition of PTs in the PRE. In vitro, the tissue-relative concentrations of TPT, tributyltin, and DBT-induced lipid disruption by activating the finless porpoise peroxisome proliferator-activated receptor α/γ (npPPARα/γ). In silico simulations further revealed a higher toxic potential of PTs than BTs on npPPARα/γ. Our results underscore the urgency for further monitoring and elimination of PTs in China.

100 Deals associated with Para-Toluenesulfonamide

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R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Non-Small Cell Lung Cancer	China	Tianjin Hongri Jiandakang Medical Technology Co Ltd	15 Nov 2022

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Adenoid Cystic Carcinoma	Phase 1	China	Tianjin Hongri Jiandakang Medical Technology Co Ltd	15 May 2014
Adenoid Cystic Carcinoma	Phase 1	China	Tianjin Chase Sun Pharmaceutical Co., Ltd.	15 May 2014
Hepatocellular Carcinoma	Phase 1	China	Tianjin Hongri Jiandakang Medical Technology Co Ltd	15 May 2014
Hepatocellular Carcinoma	Phase 1	China	Tianjin Chase Sun Pharmaceutical Co., Ltd.	15 May 2014
Airway Obstruction	Phase 1	China	Beijing Jiandakang New Drug Development Co Ltd	30 Oct 2009
Non-Small Cell Lung Cancer	Phase 1	China	Pts International Inc	01 Aug 2009
occlusions	Phase 1	China	Pts International Inc	01 Aug 2009
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency	Phase 1	China	-	22 Apr 2005
Lung Cancer	Phase 1	China	-	22 Apr 2005
Advanced Malignant Solid Neoplasm	Preclinical	China	-	12 Aug 2005