Lansoprazole/Sodium Bicarbonate

Healthy subjects were used as test subjects, lansoprazole sodium bicarbonate dry suspension (15mg/1680mg) was used as the test preparation, and lansoprazole enteric-coated capsules (Takepron®, 15mg) was used as the reference preparation. Single and multiple dosing test designs were used to conduct pharmacokinetic and pharmacodynamic comparison tests of the two preparations and the effect of food on the PK parameters of the test preparation: 1. Compare the pharmacokinetic parameters of the test preparation and the reference preparation after single and multiple dosing; 2. Compare the pharmacodynamic parameters of the test preparation and the reference preparation after single and multiple dosing; 3. Evaluate the effect of food on the pharmacokinetic parameters of the test preparation; 4. Observe the safety of the test preparation and the reference preparation in healthy Chinese subjects.