A study was conducted to evaluate the effect of feeding different metabolizable energy (ME) and crude protein (CP) levels on performance of Aseel chicken during 0 to 8 weeks of age (Juvenile phase). At 1 day old, 432 chicks were randomly distributed into nine groups. Each group had 48 chicks distributed into eight replicates with six birds in each. Maize-soybean meal-based diets with three ME levels (2,400, 2,600 and 2,800 kcal/kg) and three CP levels (16%, 18% and 20%) were fed to birds in a 3 × 3 factorial design. Different ME levels had significant effect on body weight gain (BWG), feed intake and feed conversion ratio (FCR). Birds fed diet with 2,400 kcal/kg ME had significantly lower BWG (P < 0.004), lower shank length (P < 0.0007), higher feed intake (P < 0.0001) and poor FCR (P < 0.0001) than those fed diet with either 2,600 or 2,800 kcal/kg ME. Energy efficiency ratio was not influenced by ME, CP or their interaction. However, protein efficiency ratio was significantly higher at higher ME levels and lower at higher CP levels. There was significant effect of ME, CP and their interaction on serum protein and cholesterol levels. However, they made no significant effect on antibody titre against New Castle disease vaccine. The study concluded that provision of 2,600 kcal/kg ME and 16% CP would be ideal for optimum growth of Aseel birds during juvenile phase. However, to obtain better FCR, feeding Aseel birds with diet having 2,800 kcal/kg ME and 16% CP would be ideal.