Delving into the Latest Updates on Azithromycin Fumarate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

50S subunit

Action

inhibitors

Mechanism

50S subunit inhibitors(50S ribosomal subunit inhibitors)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC42H76N2O16

InChIKeyCJGFZUQRAPSVLZ-OAWJXUPESA-N

CAS Registry910239-90-6

This study will enroll patients with Bacterial Sinusitis who will be treated with either Zmax (Azithromycin Extended Release) or Augmentin (Amoxicillin/Clavulanate). The purpose of the study is to compare early resolution of symptoms between the two treatments. Patients will report resolution of their sinusitis symptoms through a daily questionnaire. There will be two follow-up telephone interviews on days 12 and 28 to evaluate quality of life, satisfaction with therapy, and use of healthcare services.

Start Date01 Jun 2006

Sponsor / Collaborator

Pfizer Inc.

100 Clinical Results associated with Azithromycin Fumarate

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100 Translational Medicine associated with Azithromycin Fumarate

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100 Patents (Medical) associated with Azithromycin Fumarate

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2

Literatures (Medical) associated with Azithromycin Fumarate

01 Jan 2024·Dyes and Pigments

A novel luminescent Ni(II) coordination compound for highly selective detection of acetylacetone, MnO4−, tetracycline and Ag+ in aqueous systems

Author: Yan, Wen-Fu ; Jin, Juan ; Zhang, Hui-Jie ; Wang, Gang ; Zhang, Jia-Jia ; Liu, Xi-Guang ; Dong, Hao ; Wang, Yuan-Peng ; Lu, Jing ; Wang, Yu-Chang

A new Ni(II) compound [Ni(bim)2(H₂O)4] (1,5-nds).(H₂O)_0.5 1 (bim = benzimidazole, 1,5-nds-Na = disodium 1,5-naphthalenedisulfonate) was readily synthesized at room temperatureAlthough compound 1 is only a mononuclear compound, it is extended into a 2D supermol. layer by hydrogen bonding interactions.Hirshfeld surfaces and fingerprint maps of compound 1 crystal packing were calculated to gather information on non-covalent interactions.Photoluminescence experiments showed that 1 not only possessed good solid-state fluorescence performance but also favorable fluorescence characteristics and stability in aqueous solutions, which can be exposed to acidic and alk. environmental conditions (pH = 1-14) for a long time.Remarkably, compound 1 displayed outstanding anti-interference properties, high sensitivity, high quenching rate, and low limit of detection (LOD) against acetylacetone (acac), MnO^-4, and tetracycline (TET) in water media via the Turn-Off effect (LOD:7.03 μM for acac, 2.92 μM for MnO^-4 and 0.65 μM for TET).Especially, compound 1 can also be used as a rare ratiometric fluorescent probe for the detection of Ag⁺ down to the nM level.The exceptional multi-responsive performance suggested that compound 1 could be a potential multifunctional sensor.Furthermore, possible mechanisms were systematically investigated.

Taishan Yixueyuan Xuebao

Experimental evaluation of in vivo antibacterial activities and safety of azithromycin fumarate in mice

Author: Wang, Li ; Mi, Ning ; Zhao, Xiao-min ; Xin, Xiao-ming ; Gao, Yun-sheng ; Sun, Feng-bin

In vivo antibacterial activities and safety of azithromycin fumarate (AMF) were evaluated in comparison with azithromycin (AM) and erythromycin (EM).The mice general infection models were established by i.p. injecting Staphylococcus aureus and Streptococcus hemolyticus, resp.And the protective effects of AMF, AM and EM administered intragastrically against the mice infected were investigated.After single intragastric dosing, the toxic symptoms and the number of deaths of azithromycin fumarate were observed for seven days in normal mice.The ED50 values of AMF in mice infected by Staphylococcus aureus and Streptococcus hemolyticus were 33.38 and 18.25 mg·kg^-1, AM were 58.22 and 17.81 mg·kg^-1, and EM were 116.92 and 47.51 mg·kg^-1, resp.The LD50 value of AMF administered intragastrically was 3273.4 mg·kg^-1 in the normal mice.The chemotherapeutic indexes of AMF were 98.1 and 179.4 in the mice infected by Staphylococcus aureus and Streptococcus hemolyticus.AMF and AM showed higher in vivo antibacterial activities against mice infected by Staphylococcus aureus and Streptococcus hemolyticus than EM.The protective effects of AMF against the mice infected by Staphylococcus aureus were better than AM, and both of them have similar effects on the mice infected by Streptococcus hemolyticus.

100 Deals associated with Azithromycin Fumarate

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