Last update 20 Dec 2025

Aprepitant/Palonosetron

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
QLM2010
Target
HTR3 x NK1R
Action
antagonists
Mechanism
5-HT3 receptor antagonists(5-hydroxytryptamine receptors, ionotropic (HTR3) antagonists), NK1R antagonists(Neurokinin 1 receptor antagonists)
Therapeutic Areas
Other Diseases
Active Indication
Chemotherapy-induced nausea and vomiting
Inactive Indication-
Originator Organization
Qilu Pharmaceutica Hainanco Ltd.Qilu Pharmaceutica Hainanco Ltd.
Active Organization
Qilu Pharmaceutica Hainanco Ltd.Qilu Pharmaceutica Hainanco Ltd.
Inactive Organization-
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC23H21F7N4O3
InChIKeyATALOFNDEOCMKK-OITMNORJSA-N
CAS Registry170729-80-3
View All Structures (3)

Related

4
Clinical Trials associated with Aprepitant/Palonosetron
NCT07081256
/ CompletedPhase 3
A Multicenter, Randomized, Double-blind, Double-dummy, Positive-controlled Phase III Trial, to Evaluate the Efficacy and Safety of QLM2010 for Prevention of Chemotherapy-induced Nausea and Vomiting After Highly Emetogenic Chemotherapy
CTR20242556
/ CompletedPhase 3
QLM2010预防高致吐风险化疗方案引起的恶心、呕吐的多中心、随机、双盲、阳性药物平行对照的有效性和安全性临床研究
[Translation] A multicenter, randomized, double-blind, positive drug parallel controlled clinical study on the efficacy and safety of QLM2010 in preventing nausea and vomiting caused by high-emetic risk chemotherapy regimens
CTR20243278
/ CompletedPhase 1
QLM2010静脉2分钟给药的药代动力学对比研究
[Translation] Comparative study on the pharmacokinetics of QLM2010 after 2-minute intravenous administration
100 Clinical Results associated with Aprepitant/Palonosetron
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100 Translational Medicine associated with Aprepitant/Palonosetron
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100 Patents (Medical) associated with Aprepitant/Palonosetron
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100 Deals associated with Aprepitant/Palonosetron
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chemotherapy-induced nausea and vomitingNDA/BLA
China
Qilu Pharmaceutica Hainanco Ltd.Qilu Pharmaceutica Hainanco Ltd.
15 Dec 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
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Approval

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Regulation

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