Last update 07 Nov 2024

PM-8003

Overview

Basic Info

Drug Type
Trispecific antibody
Synonyms
PM 8003, PM8003
Target
PDL1 x TGF-β x VEGF
Mechanism
PDL1 inhibitors(Programmed death-ligand 1 inhibitors), TGF-β inhibitors(Transforming growth factor beta inhibitors), VEGF inhibitors(Vascular endothelial growth factor inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid Neoplasm
Inactive Indication-
Originator Organization
Pumis Biotechnology (Zhuhai) Co., Ltd.Pumis Biotechnology (Zhuhai) Co., Ltd.Startup
Active Organization
Pumis Biotechnology (Zhuhai) Co., Ltd.Pumis Biotechnology (Zhuhai) Co., Ltd.Startup
Inactive Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with PM-8003
CTR20211844 / RecruitingPhase 1/2
评价PM8003注射液在晚期实体肿瘤患者中的耐受性、安全性、药代动力学特征及初步疗效的I期临床试验及在晚期实体瘤中考察初步疗效的IIa期临床试验
[Translation] Phase I clinical trial to evaluate the tolerability, safety, pharmacokinetic characteristics and preliminary efficacy of PM8003 injection in patients with advanced solid tumors and Phase IIa clinical trial to examine the preliminary efficacy in patients with advanced solid tumors
ChiCTR2100049391 / SuspendedPhase 1IIT
Phase I clinical trial to evaluate the tolerability, safety, pharmacokinetic characteristics and primary efficacy of PM8003 injection in patients with advanced solid tumors and Phase IIa clinical trial to evaluate the primary efficacy of PM8003 injection in advanced solid tumors
100 Clinical Results associated with PM-8003
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100 Translational Medicine associated with PM-8003
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100 Patents (Medical) associated with PM-8003
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100 Deals associated with PM-8003
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
CN
Pumis Biotechnology (Zhuhai) Co., Ltd.Pumis Biotechnology (Zhuhai) Co., Ltd.Startup
31 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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