Benactyzine Methobromide

Five quaternary ammonium salts administered orally did not influence the stomach emptying rate of phenol red.On the other hand, when these quaternary ammonium salts were administered subcutaneously, a retardation of stomach emptying rate was observed thirty min after oral administration of phenol red and its extent was given in the following order, isopropamide iodide [71-81-8] >benzilonium bromide (I) [1050-48-2] >benactyzine methobromide [3166-62-9] = anisotropine methobromide [80-50-2] >propantheline bromide [50-34-0].The measurement of the stomach emptying rate may be practical and useful as one of the screening tests for pharmacologic response, e.g., the anticholinergic effect of quaternary ammonium salts.Trichloroacetate [76-03-9] administered subcutaneously did not cause a fall in the stomach emptying rate of phenol red but it accelerated the reducing effect of isopropamide iodide on the stomach emptying rate of phenol red.