Last update 07 Nov 2025

mRNA-1645-CoreG28v2

Overview

Basic Info

Drug Type
Prophylactic vaccine, mRNA vaccine
Synonyms
Core-g28v2 60mer mRNA, mRNA1644v2-Core
Target
HIV envelope protein gp120
Action
inhibitors, stimulants
Mechanism
HIV envelope protein gp120 inhibitors, Immunostimulants
Therapeutic Areas
Immune System DiseasesInfectious DiseasesUrogenital Diseases
Active Indication
HIV Infections
Inactive Indication-
Originator Organization
HIV Vaccine Trials NetworkHIV Vaccine Trials Network
Active Organization
ModernaTX, Inc.International AIDS Vaccine Initiative, Inc.International AIDS Vaccine Initiative, Inc.HIV Vaccine Trials NetworkHIV Vaccine Trials Network
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with mRNA-1645-CoreG28v2
NCT06694753
/ Not yet recruitingPhase 1IIT
A Phase 1, Placebo-controlled, Blinded, Dose-escalation Study to Evaluate the Safety and Immunogenicity of mRNAs Encoding HIV Immunogens (eOD-GT8 60mer, Core-g28v2 60mer, N332-GT5 gp151) in Adult Participants Without HIV and in Overall Good Health in South Africa
NCT05001373
/ Active, not recruitingPhase 1IIT
A Phase 1, Randomized, First-in-human, Open-label Study to Evaluate the Safety and Immunogenicity of eOD-GT8 60mer mRNA Vaccine (mRNA-1644) and Core-g28v2 60mer mRNA Vaccine (mRNA-1644v2-Core) in HIV-1 Uninfected Adults in Good General Health
100 Clinical Results associated with mRNA-1645-CoreG28v2
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100 Translational Medicine associated with mRNA-1645-CoreG28v2
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100 Patents (Medical) associated with mRNA-1645-CoreG28v2
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100 Deals associated with mRNA-1645-CoreG28v2
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 1
United States
ModernaTX, Inc.
12 Nov 2021
HIV InfectionsPhase 1
United States
International AIDS Vaccine Initiative, Inc.International AIDS Vaccine Initiative, Inc.
12 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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