Cefovecin

Information on antimicrobial resistance patterns of urinary pathogens of cats can aid veterinarians in their antimicrobial prescription choices. We assessed the prevalence and antimicrobial resistance of bacteria isolated from urine samples of cats with urinary tract infections (UTIs) submitted to a veterinary diagnostic laboratory in Illinois between 2020 and 2022. The laboratory received 2026 urine samples during the study period, of which 606 (29.97%) showed bacterial growth, and from these samples, 883 bacterial strains were recovered. The most common gram-positive bacterial species included Enterococcus faecalis (n = 123), Staphylococcus felis (n = 50), and Staphylococcus pseudintermedius (n = 28), while the most common gram-negative bacteria included Escherichia coli (n = 322) and Proteus mirabilis (n = 18). Among the gram-positive isolates, none of the Enterococcus faecalis isolates showed resistance to amoxicillin-clavulanic acid and ampicillin. In addition, Staphylococcus felis isolates showed low resistance to ampicillin (7.32%), enrofloxacin (4.88%), and amoxicillin-clavulanic acid (4.88%). Among gram-negative bacteria, E. coli isolates showed a high resistance to ampicillin (30.64%), and a moderate resistance to amoxicillin-clavulanic acid (11.78%) and cefovecin (11.11%), antibiotics considered as first-line choices to treat UTIs in cats. Compared to 2020, the rate of E. coli isolates resistant to amoxicillin-clavulanic acid was lower in 2022 (IRR: 0.42; 95%; CI: 0.18-0.99). This study provides antibiograms of common feline urinary pathogens in Illinois that could aid veterinarians in their empirical UTI therapy choices. Requesting an antimicrobial susceptibility test when starting an empirical treatment could be beneficial to guide altered therapy to secure treatment success if the causative pathogens are resistant to the empirical antimicrobial choices.

Understanding antimicrobial use is a core component of antimicrobial stewardship. This study aimed to assess antimicrobial dispensing for common clinical conditions in dogs and cats presented to veterinary clinics belonging to a large clinic network in the USA. Antimicrobials were prescribed for 831,017 patient visits, to 702,576 (85 %) dogs and 128,441 (15 %) cats. Cefpodoxime (n = 203,145, 29 %), amoxicillin-clavulanate (154,779, 22 %) and metronidazole (150,830, 21 %) were the most commonly dispensed antimicrobials in dogs, while cefovecin (55,579, 43 %) and amoxicillin-clavulanate (44,857, 35 %) predominated in cats. In dogs, drugs classified by the WHO MIA List as highest priority critically important (HPCIA) accounted for 39 % of drugs dispensed, while those classified as highly important (HIA) accounted for 61 %. In cats, HPCIA drugs accounted for 46 % of drugs dispensed while HIA drugs accounted for 54 %. Consistency of drug selection with selected treatment guidelines was 76 % (30,562/40,375) for dogs and 57 % (12,810/22,644) for cats. There were regional differences in drug selection patterns for all of the 10 most common diseases, for both dogs and cats. While no single metric or data source provides a full understanding of antimicrobial use, these data provide the foundation for assessment of antimicrobial use practices and provide insight and baseline data for development of interventions to improve antimicrobial use practices.