Author: Sadao Manabe ; Toyokazu Ishikawa ; Shigeharu Ueda ; Toshiyuki Onishi ; Yasuyuki Gomi ; Akiko Kikukawa ; Masateru Akechi ; Junko Namazue ; Yoshinobu Okuno ; Isao Fuke

Japanese encephalitis is an infectious disease caused by the Japanese encephalitis virus, which is widespread throughout Asia. The worldwide incidence is 50,000 cases per year. There is no specific treatment available, but inactivated mouse brain-derived vaccine was used from the 1950s to prevent infection. However, quality control of mouse brain-derived vaccines is difficult, and therefore a new freeze-dried, cell culture-derived Japanese encephalitis vaccine (inactivated) (JEBIK V; development code: BK-VJE) was developed. In this paper, we report an analysis of neutralizing antibody titers in vaccinated subjects enrolled in clinical study of BK-VJE at various doses, and study of BK-VJE with the mouse brain-derived vaccine as a control. The results show that BK-VJE has superior immunogenicity compared to mouse brain-derived vaccine.

Toxicological European Research

Biliary excretion of vanadium in rats

Author: Rade, J. ; Manzo, L. ; Gregotti, C. ; Sabbioni, E. ; Marafante, E. ; Dinucci, A.

The biliary excretion of V was studied in bile duct-cannulated rats at various times after the i.v. administration of a single dose of ⁴⁸V-labeled pentavalent V.The tissue disposition, hepatic intracellular distribution, and binding of ⁴⁸V to plasma, bile, and liver components were also investigated.During the 1st 6 h after the injection of V, 0.9-30 μg/kg, <2% of the dose was excreted into the bile and ≤20% of V was eliminated in the urine.The bile flow was markedly decreased in rats cannulated 24 h after the injection of V (30 μg/kg), while higher doses produced signs of severe toxicity immediately after administration.Evidence was also obtained that a concentration gradient triggers the passage of V from plasma to the liver, where only a fractional amount becomes available for canalicular excretion, due to the extensive binding of the metal to organelles and other tissue ligands.

100 Deals associated with Freeze-dried, Cell Culture-derived Japanese Encephalitis Vaccine

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	J07BA02	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Encephalitis, Japanese	Japan	Osaka University	23 Feb 2009

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Freeze-dried, Cell Culture-derived Japanese Encephalitis Vaccine

Overview

Basic Info

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation