PURPOSETo establish a reliable method and efficient contrast agent for selective MR imaging of articular cartilage to improve the diagnosis of cartilage disorders.MATERIALS AND METHODSA standard trace element replenisher (Mineric), which includes manganese chloride, cupric sulfate (both positive MR contrast agents), and colloidal ferric chloride (a negative contrast agent), was evaluated in comparison with gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) as a potential contrast agent. Normal saline was used as a control. The agents were injected into bilateral knee joints, and the entire joint block was dissected. Coronal images of femorotibial joints were obtained at 7.05 Tesla. Signal intensity ratios (SIRs) of cartilage to joint fluid were calculated for T1 and T2 values. The side effects of the agents were also investigated. Finally, histological evaluations were performed.RESULTSSIRs were significantly increased in the Mineric treatment group compared with the Gd-DTPA and saline treatment groups. The T1 values of cartilage and fluid were significantly decreased in the Gd-DTPA and Mineric treatment groups. The T2 values of fluid were significantly decreased in the Mineric treatment group. No apparent side effects or degenerative changes in the joints were observed.CONCLUSIONA clinical trace element mixture was used as a novel double-contrast agent, and it exhibits selective MR contrast in articular cartilage.

01 Jan 2001·Internal MedicineQ4 · MEDICINE

Short-term Administration of an Essential Trace Elements Preparation (Elemenmic) Causes a High Whole Blood Manganese Concentration and Manganese Deposition in Basal Ganglia.

Q4 · MEDICINE

Article

Author: OZAWA, Eisuke ; ORIMO, Satoshi

100 Deals associated with Ferric Chloride/Manganese Chloride/Zinc Sulfate Hydrate/Cupric Sulfate/Potassium Iodide

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Dietary Supplement	CA	Sandoz Canada, Inc.	15 May 2023
Nutritional and Metabolic Diseases	JP	Fuji Yakuhin Co., Ltd.	09 Mar 1999
Nutrition Disorders	JP	AY Pharmaceuticals Co Ltd.	21 Jan 1992

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Ferric Chloride/Manganese Chloride/Zinc Sulfate Hydrate/Cupric Sulfate/Potassium Iodide

Overview

Basic Info

Structure

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation