Last update 01 Mar 2025

Linaprazan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Front-loaded, AR-H044277, AZD 0865
+ [5]
Mechanism
H+/K+ ATPase blockers(Potassium-transporting ATPase blockers)
Active Indication
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC21H26N4O2
InChIKeyGHVIMBCFLRTFHI-UHFFFAOYSA-N
CAS Registry248919-64-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Erosive esophagitisPhase 2
US
01 May 2004
Erosive esophagitisPhase 2
CA
01 May 2004
Erosive esophagitisPhase 2
DK
01 May 2004
Erosive esophagitisPhase 2
FI
01 May 2004
Erosive esophagitisPhase 2
FR
01 May 2004
Erosive esophagitisPhase 2
DE
01 May 2004
Erosive esophagitisPhase 2
IT
01 May 2004
Erosive esophagitisPhase 2
NO
01 May 2004
Erosive esophagitisPhase 2
SE
01 May 2004
Erosive esophagitisPhase 2
GB
01 May 2004
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
35
Linaprazan glurate+Clarithromycin
(Part I)
jgkkqlxgnf(nkjslckabk) = taaunhqqvn lzwhmcwlnd (ygrclymodt, cqtwftroch - vfuyhnrzat)
-
03 Jan 2025
Linaprazan glurate hydrochloride (HCl)+Midazolam
(Part II)
gqxfqgjcwu(lbqukycetx) = xhndwxfodn rpebxorsdt (vxoweqbabb, yrkqtgrvfz - rsgydzinwn)
Not Applicable
-
xedapykmoy(uzhxjklirf) = In the double-blind period (Week 1-4), treatment-emergent adverse events (TEAEs) were reported by 18.2% of patients treated with LG (all 4 doses), and by 18.0% of patients treated with LAN. 2 patients (0.8%) experienced serious TEAEs (25 mg dosing group: severe cholecystitis; 75 mg dosing group: moderate laryngospasm), with both events being considered by the Investigator as unlikely related to study treatment. 8 patients (3.2%) presented with at least one TEAE considered by the Investigator as related to study drug. Treatment was discontinued in 5 patients (2.0%) due to TEAEs (25 mg dosing group: severe cholecystitis, mild diarrhea; 100 mg dosing group: moderate esophageal pain, moderate regurgitation; lansoprazole group: mild nausea, mild chest pain, mild fatigue, mild COVID-19). For the entire study period (Week 1-8), TEAEs were reported by 23.0% of patients. The most commonly reported TEAEs are presented in Table 1. No deaths, nor any adverse events of special interest, were reported in the study. No notable differences between the treatment groups were observed with regards to clinical laboratory evaluation, vital signs, physical findings, or other observations related to safety. wrncneiqhy (iddbrkbycf )
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15 Oct 2023
Linaprazan glurate 50 mg
Not Applicable
-
-
Linaprazan glurate 25 mg BID
zruojxoqko(tqfcxtaqsi) = qvbjvksoiy tyjsassmry (stfyxpbfez, 59.7 - 84.7)
-
15 Oct 2023
Linaprazan glurate 50 mg BID
zruojxoqko(tqfcxtaqsi) = ewaiomuufm tyjsassmry (stfyxpbfez, 73.8 - 91.1)
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Regulation

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