Last update 21 Jul 2025

C-6354

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
EGFR C797S x EGFR L858R x EGFR T790M x EGFR-Ex19del
Action
degraders
Mechanism
EGFR C797S degraders(Epidermal Growth Factor Receptor C797S degraders), EGFR L858R degraders(EGFR exon 21 L858R mutation degraders), EGFR T790M degraders(Epidermal Growth Factor Receptor T790M degraders)
Therapeutic Areas
NeoplasmsRespiratory Diseases
Active Indication
EGFR C797S Mutation Non-small Cell Lung CancerEGFR exon 19 Deletions Mutant Non-small Cell Lung CancerEGFR T790M Mutation Positive Non-Small Cell Lung Carcinoma
Inactive Indication-
Originator Organization
Cyrus Therapeutics, Inc.Cyrus Therapeutics, Inc.
Active Organization
Cyrus Therapeutics, Inc.Cyrus Therapeutics, Inc.
Inactive Organization-
License Organization
Cyprus Therapeutics, Inc.Bridge Biotherapeutics, Inc.Bridge Biotherapeutics, Inc.
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with C-6354
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100 Translational Medicine associated with C-6354
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100 Patents (Medical) associated with C-6354
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100 Deals associated with C-6354
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
EGFR C797S Mutation Non-small Cell Lung CancerPreclinical
China
Cyrus Therapeutics, Inc.Cyrus Therapeutics, Inc.
-
EGFR exon 19 Deletions Mutant Non-small Cell Lung CancerPreclinical
China
Cyrus Therapeutics, Inc.Cyrus Therapeutics, Inc.
-
EGFR T790M Mutation Positive Non-Small Cell Lung CarcinomaPreclinical
China
Cyrus Therapeutics, Inc.Cyrus Therapeutics, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Clinical Trial

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Approval

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Regulation

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