Delving into the Latest Updates on 1'-Cyanocytidine with Synapse

Overview

Basic Info

Drug Type

Nucleic acid drugs

Synonyms

CNC

Target

RNA polymerase

Action

inhibitors

Mechanism

RNA polymerase inhibitors

Therapeutic Areas

Infectious DiseasesRespiratory Diseases

Active Indication

COVID-19

Inactive Indication-

Originator Organization

Emory University School of Medicine

Active Organization

Emory University School of Medicine

Inactive Organization-

License Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Oral biofilms are key contributors to the development of dental caries and various periodontal diseases. Streptococcus mutans is a primary bacterium responsible for causing dental caries. Dental implants are frequently used to replace missing teeth, but biofilm accumulation on these implants is a major factor in implant failure. In the realm of dentistry, metal organic framework (MOFs) has shown potential in addressing the prevalent issue of dental caries, commonly known as tooth decay. ZIF-8 provides pH-responsive Zn²⁺ release in acidic environments typical of dental caries. Carbon nanocrystals (CNC) and gold nanoparticles (AuNPs) are biocompatible nanoparticles that generate reactive oxygen species (ROS) under light and enhance antibacterial effects. Together, they offer targeted, dual-action antibacterial power. Cariogenic bacteria or their metabolic by products can be selectively captured from saliva or dental plaque using functionalized MOFs (Au/ZIF-8 and CNCs/ZIF-8). This investigation explores the antibacterial efficacy of ZIF-8-derived nanocomposites (Au-Np/ZIF-8 and CNC/ZIF-8) in neutralizing the decay-promoting properties of Streptococcus mutans. Fundamental virulence characteristics of S. mutans biofilm architecture includes metabolic acid production, environmental acid resistance, and exopolysaccharide (EPS) matrix formation. In-vitro investigations demonstrated a reduction in growth of biofilm by 64.31% (Au/ZIF-8) and 68% (CNC/ZIF-8). The results showed that treating with sub-MIC concentrations of CNC/ZIF-8 reduced EPS formation by over 51%. The present investigation represents the inaugural assessment of CNC/ZIF-8 nanocomposites as potential surface modification materials for dental implant applications. Acrylic substrates treated with CNCs/ZIF-8 demonstrated substantial inhibition of S. mutans biofilm (95% reduction). Its biocompatible properties make this nanocomposite ideal for coating implants.

01 Mar 2026·OTOLOGY & NEUROTOLOGY

Evaluating Cochlear Implantation Outcomes in Charcot-Marie-Tooth Disease: A Case Series Analysis of Genetic Profiles and Intervention Timing

Article

Author: Stucken, Emily Z. ; Hughes, Sarah E. ; Mehta, Anahita H.

Objective::

Charcot-Marie-Tooth disease (CMT) is a hereditary neuropathy that may present with sensorineural hearing loss (SNHL) or auditory neuropathy spectrum disorder (ANSD). Cochlear implants (CIs) have been used to rehabilitate hearing loss in CMT, but their effectiveness remains poorly understood due to the central and peripheral neurological complexities of the disease.

Study design::

Clinical capsule report.

Patients::

Two adult CMT patients and 2 pediatric CMT patients.

Intervention::

Cochlear implantation.

Main outcome measures::

Preoperative clinical profiles and postoperative auditory performance.

Results::

Case 1: A 60-year-old woman with bilateral ANSD and comorbid multiple sclerosis (MS) achieved significant speech perception improvement (CNC: 8%–68%, AzBio: 64%) 1 year post-CI. Case 2: A 20-month-old boy with GJB1 -associated CMT1X and developmental delays exhibited rapid auditory gains (MLNT: 100%) following CI. Case 3: A 12-year-old boy with AIFM1 -related ANSD and mitochondrial dysfunction achieved moderate speech recognition (CNC: 56%, AzBio: 75%) but remained limited in noisy environments. Case 4: A 32-year-old man with PRPS1 -associated CMTX5 and profound prelingual SNHL showed improved sound awareness (20–30 dB HL) post-CI but had no speech perception gains due to prolonged auditory deprivation.

Conclusions::

Cochlear implantation in CMT patients demonstrates variable but meaningfully beneficial auditory outcomes, with early intervention yielding the most favorable results. A personalized approach incorporating genetic profiling, tailored rehabilitation strategies, and setting realistic patient expectations is essential to optimizing outcomes.

01 Feb 2026·FOOD CHEMISTRY

Pinus Knraiensis Nut skin derived CNC reinforced antibacterial chitosan/gum arabic films incorporating Ocimum gratissimum L. essential oil for packaging beef

Article

Author: Xu, Hongyan ; Wang, Yuchen ; Wang, Ruixuan ; Ge, Zhenying ; Zhang, Song ; Yin, Lu ; Xia, Guangjun ; Jin, Zhiyan ; Zhao, Duanduan

Natural polysaccharide-based film suffers lower strength which will further decrease by adding essential oil to endow antibacterial activity. Herein, cellulose nanocrystals (CNC) prepared from Pinus Knraiensis Nut skin (PKNS) was incorporated in gum arabic (GA)/chitosan (CS) composite film. PKNS CNC exhibited needle-like shape and higher stability due to zeta potential of lower than -30 mV. After it was added into GA/CS film, the biocompatibility among them was better and the strength, barrier to moisture and hydrophobicity of GA/CS film were improved. Ocimum gratissimum L. essential oil (OGEO) was blended in GA/CS/CNC film to access obvious antibacterial property against E. coli, Salmonella and S. aureus. Compared to Yanbian cattle beef without package and packed with GA/CS and GA/CS/CNC, that packaged by the antibacterial composite film showed the best quality recognized by the redder color, slowest improved pH value, lowest content of thiobarbituric acid reactive substances (TBARS) and Total volatile basic nitrogen (TVB-N).

100 Deals associated with 1'-Cyanocytidine

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