Phytochemical composition, phytotoxicity, and ADME modeling of Artemisia absinthium L.: implications for food safety and pharmaceutical applications

Author: Mothana, Ramzi A. ; Hbika, Asmae ; Farihi, Ayoub ; Gharibi, Elkhadir ; Ed-darraz, Fatima-Zahrae ; Hawwal, Mohammed F. ; Benali, Mohammed ; Bouyanzer, Abdelhamid

Artemisia absinthium, an aromatic herb distinguished by its characteristic bitter flavor, has been used in a variety of culinary applications.This study investigates its metabolites through phytochem. methods.The primary minerals in Artemisia absinthium stems are potassium (41%) and calcium (38.3%), forming most of its mineral content.The ethanolic extract exhibited the highest phenolic compound content, with 37.6 ± 0.09 mg GAE/g DE.The primary volatile compound identified was β-thujone, comprising over 26.6% of the volatile content.Palmitic acid is the predominant fatty acid in the hexanic extract (18.7%), while linoleic acid is the main fatty acid in the Et acetate extract (42.4%).Twenty phenolic compounds were identified, with 8-methoxyflavone, (+)-catechin hydrate, and chlorogenic acid as major compounds in dichloromethane, Et acetate, and ethanol extracts, resp.ADME modeling indicating that 8-methoxyflavone, a major component in the dichloromethane extract, is a promising candidate for drug development targeting the central nervous system.

01 Jun 2025·Fluid Phase Equilibria

Acidic deep eutectic systems and their capacity to increase drug bioavailability

Author: Duarte, Ana Rita C. ; Fernandes, Claudio C. ; Ferreira, Ines J.

The pharmaceutical industry faces several challenges concerning the bioavailability of novel medications mainly because of their limited permeability and/or solubilityThese are two crucial features that influence how well a medication is absorbed.The biopharmaceutics categorization system is a crucial instrument for the classification of active pharmaceutical ingredients (API) based on their permeability and solubilityIn this work we explored the possibility of deep eutectic systems (DES) to be used as solubility and permeability enhancers of four different drugs supplied by Boeringher Ingelheim.In this investigation, the API′s were dissolved in various DES and their solubility measured in PBS at 37 °C.Our findings suggest that CA: Gly: W (1:1:1) was able to increase the solubility of all four drugs in PBS, as well as their permeability.In summary, BI0001 and BI0002 following pre-solubilization in that system drugs shifted from class III to from class I included, whereas BI0005 still kept its class III classification although having higher solubility and permeability.The encouraging outcomes highlight DES′s potential as a technique to boost drug′s bioavailability.

01 Jun 2025·Food Chemistry

Sensomics and chemometrics approaches of differential brewed and roasted coffee (Coffea arabica) from Ethiopia using biomimetic sensory-based machine perception techniques: Effects of caffeine on bitter taste and the generation of volatiles

Article

Author: Yu, Se Young ; Moon, Hee Sung ; Ban, Younglan ; Shin, Eui-Cheol ; Park, Hyeonjin ; Hong, Seong Jun

This study investigated the effects of caffeine in coffee extract (CE) prepared under various roasting and brewing conditions on non-volatile characteristics (antioxidant activity, caffeine contents, chlorogenic acid contents, and taste patterns) and volatile compounds. The representative taste of coffee is bitter taste, and it was mainly influenced by roasting processes compared with the contents of caffeine. Non-volatile compounds were influenced by the bean types (regular and decaffeinated beans) and brewing methods, whereas volatile compounds were mainly affected by the brewing methods and roasting processes. In chemometrics approaches, the correlation between caffeine and bitterness (-0.003) and sourness (0.549) was identified. The correlation between chlorogenic acid and bitterness (0.399) and sourness (0.693) was identified. This study is expected to serve as a basis for understanding changes in bitterness and the generation of volatile compounds according to the contents of caffeine.

100 Deals associated with 2-Camphanone

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-	2-Camphanone	-	DB14156

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