Delving into the Latest Updates on Acetic acid, glacial/Aluminum acetate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

BOROFAIR, DOMEBORO

Target-

Mechanism-

Therapeutic Areas

Otorhinolaryngologic Diseases

Active Indication-

Inactive Indication

Infection of ear

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseWithdrawn

First Approval Date-

Regulation-

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Structure

Molecular FormulaC6H12AlO6

InChIKeyRGUQYKWBLSHQCY-UHFFFAOYSA-N

CAS Registry139-12-8

View All Structures (2)

The in vitro activity of prophylactic ear drops (Otic Domeboro) which are widely used by saturation divers against external otitis has been assessed. Four strains of Pseudomonas aeruginosa, 1 reference strain and 3 clinical isolates from cases of external otitis were employed. Two of the clinical isolates were from saturation divers who were using Otic Domeboro. Otic Domeboro solution was bactericidal even when diluted 1:2 in serum or broth. There were no significant differences between strains. There was no measurable inoculum effect. Survival kinetic analysis showed 60% killing at 5 min and 99.9% killing at about 2 h. Otic Domeboro is an effective anti-P. aeruginosa agent. There was no evidence of increased resistance among strains isolated from divers. The rate of killing in relation to usual prophylactic recommendations suggests that frequent dripping may be more effective. The therapeutic use of Otic Domeboro in saturation diving should be evaluated to avoid unnecessary use of antibiotic drops.

100 Deals associated with Acetic acid, glacial/Aluminum acetate

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