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Last update 08 May 2025

Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/PEG 4000, 塩化ナトリウム/塩化カリウム/炭酸水素ナトリウム/無水硫酸ナトリウム/ポリエチレングリコール 4000

+ [2]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Intestinal Diseases

Inactive Indication-

Originator Organization

EA Pharma Co., Ltd.

Active Organization

EA Pharma Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Japan (27 Mar 1992),

Intestinal Diseases

Regulation-

Structure/Sequence

Molecular FormulaClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS Registry7647-14-5

View All Structures (5)

Clinical Trials associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

JPRN-JapicCTI-070431

/ Unknown statusPhase 3

Phase 3 clinical trial of a combination of MGV-5 and AS-4370 as pretreatment for barium enema X-ray radiography

Start Date-

Sponsor / Collaborator

EA Pharma Co., Ltd.

100 Clinical Results associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

100 Translational Medicine associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

100 Patents (Medical) associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

Literatures (Medical) associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

01 Jan 2019·Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology

[Anaphylactic shock secondary to the use of macrogol 4000 as a bowel cleanser:a case report].

Article

Author: Sanomura, Tamana ; Iishi, Hiroyasu ; Ouchi, Shohei ; Tsutsui, Shusaku ; Horiki, Masashi ; Imanaka, Kazuho ; Murayama, Yoko ; Ogiyama, Hideharu ; Seto, Kayo ; Nasu, Ayaka

A 44-year-old man was administered Niflec^® containing macrogol 4000 as a bowel cleanser for colonoscopic examination. Immediately after ingestion, he experienced oral cavity discomfort and nasal congestion, followed by acute urticaria and presyncope. His systolic blood pressure and peripheral capillary oxygen saturation dropped to 66mmHg and 89%, respectively. Fluid infusion, as well as steroid and epinephrine administration, improved his symptoms. Skin prick tests were then performed using Niflec^®, macrogol 4000, and Actosin^® ointment (containing macrogol 4000), all of which were positive. Therefore, the patient was diagnosed with anaphylactic shock caused by macrogol 4000 included in Niflec^®. Macrogol present in bowel cleansers used for colonoscopy rarely causes anaphylactic shock. However, clinicians need to be mindful of this risk. Prompt and appropriate treatment is needed should this condition occur.

Case Reports in Gastroenterology

Colonic Diverticular Bleeding Associated with Bowel Cleansers before Colonoscopy

Author: Kubo, Kimitoshi ; Kato, Mototsugu ; Tsuda, Momoko ; Kimura, Noriko ; Matsuda, Soichiro

To date, colonic diverticular bleeding associated with bowel cleansers has not been reported, and its endoscopic and pathological features remain largely unclear. We report a case of colonic diverticular bleeding associated with a bowel cleanser (137 g of polyethylene glycol [NIflec®]) before colonoscopy (CS). CS revealed colonic diverticular bleeding in the sigmoid colon. To our knowledge, this is the first report describing the endoscopic and pathological features of colonic diverticular bleeding associated with bowel cleansing before CS.

100 Deals associated with Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Intestinal Diseases	Japan	EA Pharma Co., Ltd.	27 Mar 1992

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Sodium Chloride/Potassium Chloride/Sodium Bicarbonate/Anhydrous Sodium Sulfate/Macrogol 4000

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation