This trial is to compare the efficacy and safety of modified FOLFOX6 [mFOLFOX6, a specific chemotherapy regimen of Oxaliplatin ,5-Fluorouracil and Leucovorin] chemotherapy plus Antigen Pulsed Dendritic Cells (APDC，a kind of autologous tumor lysates pulsed human dendritic cells vaccine) with modified chemotherapy alone in patients with metastatic colorectal cancer.

Start Date01 Jul 2015

Sponsor / Collaborator

The Second Military Medical University

[+14]

100 Clinical Results associated with Antigen Pulsed Dendritic Cells(Shanghai Haixin Biotechnology)

100 Translational Medicine associated with Antigen Pulsed Dendritic Cells(Shanghai Haixin Biotechnology)

100 Patents (Medical) associated with Antigen Pulsed Dendritic Cells(Shanghai Haixin Biotechnology)

Literatures (Medical) associated with Antigen Pulsed Dendritic Cells(Shanghai Haixin Biotechnology)

01 Mar 2024·Heliyon

An “off-on” fluorescent nanosensor for the detection of cadmium ions based on APDC-etched CdTe/CdS/SiO2 quantum dots

Article

Author: Deng, Qi ; Lukman, Iddrisu ; Sun, Lijun ; Fang, Zhijia ; Gooneratne, Ravi ; Meng, Haimei ; Gao, Jialong ; Liao, Jianmeng ; Chen, Jiaqian

In this study, we have developed a novel fluorescent "OFF-ON" quantum dots (QDs) sensor based on CdTe/CdS/SiO₂ cores. Ammonium pyrrolidine dithiocarbamate (APDC), ethylenediamine tetraacetic acid (EDTA), and 1,10-phenanthroline (Phen) served as potential chemical etchants. Among these three etchants, APDC exhibited the most pronounced quenching effect (94.06%). The APDC-etched CdTe/CdS/SiO₂ QDs demonstrated excellent optical properties: the fluorescence of the APDC-etched CdTe/CdS/SiO₂ QDs system (excitation wavelength: 365 nm and emission wavelength: 622 nm) was significantly and selectively restored upon the addition of cadmium ions (Cd²⁺) (89.22%), compared to 15 other metal ions. The linear response of the APDC-etched CdTe/CdS/SiO₂ QDs was observed within the cadmium ion (Cd²⁺) concentration ranges of 0-20 μmol L^-1 and 20-160 μmol L^-1 under optimized conditions (APDC: 300 μmol L^-1, pH: 7.0, reaction time: 10 min). The detection limit (LOD) of the APDC-etched CdTe/CdS/SiO₂ QDs for Cd²⁺ was 0.3451 μmol L^-1 in the range of 0-20 μmol L^-1. The LOD achieved by the QDs in this study surpasses that of the majority of previously reported nanomaterials. The feasibility of using APDC-etched CdTe/CdS/SiO₂ QDs for Cd²⁺ detection in seawater, freshwater, and milk samples was verified, with average recoveries of 95.27%-110.68%, 92%-106.47%, and 90.73%-111.60%, respectively, demonstrating satisfactory analytical precision (RSD ≤ 8.26).

25 Jun 2019·Zhen ci yan jiu = Acupuncture research

[Effect of scalp acupuncture stimulation on cerebral infarct volume and expression of IL-10, IL-6 and IL-1β in para-hippocampal gyrus in acute ischemic cerebrovascular disease rats].

Article

Author: Li, Xing-Lan ; Zhao, Min ; Du, Xiao-Zheng ; Wang, Jin-Hai ; Jiang, Hua ; Zhang, Zhen-Chang ; Yuan, Bo ; Zhang, Ting-Zhuo ; Tian, Liang

OBJECTIVETo observe the influence of scalp acupuncture on cerebral infarct size and expression of IL-10, IL-6, and IL-1β in the para-hippocampal gyrus in acute ischemic cerebrovascular disease(AICD) rats, so as to investigate its mechanisms underlying improvement of AICD.METHODSForty-eight male SD rats were randomly allocated to normal control (control), AICD model, medication, and scalp acupuncture groups (n＝12 per group). The AICD model was established by occlusion of the middle cerebral artery (MCAO). Rats of the medication group received intraperitoneal injection of Ammonium 1-Pyrrolidinedithiocarbamate (APDC, 100 mg•kg^－1•d^－1), once daily for 7 days. Scalp acupuncture stimulation was applied to bilateral "Dingnieqianxiexian" (MS6) once daily for 7 days. Before and after intervention, the neurologic deficit score (NDS) and the neurological score (NS) were evaluated according to Longa's and Schäbitz's methods, respectively. At the end of the intervention, the para-hippocampal gyrus and whole brain were collected respectively. The expression levels of IL-10, IL-6 and IL-1β in the para-hippocampal gyrus tissue were detected by immunohistochemistry, and the cerebral infarct volume of the brain was detected by triphenyltetrazollium chloride (TTC) staining after sectioning.RESULTSFollowing modeling, the NDS, NS and the expression of IL-10, IL-6 and IL-1β in para-hippocampal gyrus were significantly increased in the model group compared with the control group (P<0.01). After the intervention, the NDS, NS and infarct volume, and the expression levels of IL-6 and IL-1β in the para-hippocampal gyrus were significantly decreased in both medication and scalp acupuncture groups compared with the model group (P<0.05), and the expression of IL-10 was further obviously up-regulated in the scalp acupuncture group (P<0.05) rather than in the medication group (P>0.05). The effect of scalp acupuncture was obviously superior to that of medication in up-regulating IL-10 expression level (P<0.05). No significant differences were found between the medication and scalp acupuncture groups in the levels of NDS, NS, infarct volume, IL-6 and IL-1β proteins (P>0.05).CONCLUSIONScalp acupuncture can improve neurological function and reduce infarct volume in AICD rats, which may be associated with its function in up-regulating the expression of IL-10 and in inhibiting the expression of IL-6 and IL-1β to reduce inflammation reaction.

01 Mar 2017·Food ChemistryQ1 · AGRICULTURAL & FORESTRY SCIENCE

Inorganic selenium speciation analysis in Allium and Brassica vegetables by ionic liquid assisted liquid-liquid microextraction with multivariate optimization

Q1 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Estefanía Mabel Martinis ; Rodolfo German Wuilloud ; Alexander Castro Grijalba

A highly sensitive vortex assisted liquid-liquid microextraction (VA-LLME) method was developed for inorganic Se [Se(IV) and Se(VI)] speciation analysis in Allium and Brassica vegetables. Trihexyl(tetradecyl)phosphonium decanoate phosphonium ionic liquid (IL) was applied for the extraction of Se(IV)-ammonium pyrrolidine dithiocarbamate (APDC) complex followed by Se determination with electrothermal atomic absorption spectrometry. A complete optimization of the graphite furnace temperature program was developed for accurate determination of Se in the IL-enriched extracts and multivariate statistical optimization was performed to define the conditions for the highest extraction efficiency. Significant factors of IL-VA-LLME method were sample volume, extraction pH, extraction time and APDC concentration. High extraction efficiency (90%), a 100-fold preconcentration factor and a detection limit of 5.0ng/L were achieved. The high sensitivity obtained with preconcentration and the non-chromatographic separation of inorganic Se species in complex matrix samples such as garlic, onion, leek, broccoli and cauliflower, are the main advantages of IL-VA-LLME.

100 Deals associated with Antigen Pulsed Dendritic Cells(Shanghai Haixin Biotechnology)

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Indication	Highest Phase	Country/Location	Organization	Date
Colorectal Cancer	Phase 3	CN	The Second Military Medical University	01 Dec 2015
Colorectal Cancer	Phase 3	CN	Shanghai Haixin Bio-tech Co., Ltd.	01 Dec 2015
Metastatic Colorectal Carcinoma	Phase 3	-	The Second Military Medical University	01 Jul 2015

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