Delving into the Latest Updates on Glybuzole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Glybuzole (JAN/INN)

+ [3]

Target

Kir6.2 x SUR1

Mechanism

Kir6.2 agonists(potassium inwardly rectifying channel subfamily J member 11 agonists), SUR1 inhibitors(Sulfonylurea receptor 1 inhibitors)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest Phase-

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC12H15N3O2S2

InChIKeyNMWQEPCLNXHPDX-UHFFFAOYSA-N

CAS Registry1492-02-0

Systematic polymorphic screening tests were performed using 11 kinds of solvents and 6 kinds of preparation methods, and the three specific modifications of glybuzole (forms I and II and amorphous form) were identified by X-ray diffractometry and differential thermal analysis (DTA). The physicochemical properties of forms I and II and amorphous forms were measured using X-ray diffractometry, differential scanning calorimetry (DSC), thermogravimetry (TG), scanning electron microscopy (SEM), solubility tests, and others. The solubilities of all modifications in JP XII, first and second fluid (pH 1.2 and 6.8, respectively) were evaluated at 37 degrees C. Forms I and II and the amorphous form showed almost equivalent solubilities. Forms I and II were stable polymorphic forms at 0% and 75% relative humidity (RH), respectively, at 40 degrees C for 2 months, but the amorphous form was not stable. The crystallization rates of the amorphous form at 0% and 75% RH at 40 degrees C were estimated by X-ray diffraction analysis based on the Jander equation, and the rate at 0% RH was 364 times slower than that at 75% RH.

01 Jan 1976·Nihon Shika Ishikai zasshi

[Death caused by intravenous anesthetics; thoracic pain caused by synthetic penicillin; and liver diseases induced by Glybuzole sometimes used in combination with clindamycin for the treatment of diabetes by dentists in the form of self medication].

Article

Author: Tamura, T

03 May 1971·Polski tygodnik lekarski (Warsaw, Poland : 1960)

[Clinical assessment of Gludiase in treatment of diabetes].

Article

Author: Ponikowska, I

100 Deals associated with Glybuzole

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