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Last update 14 Mar 2026
AZD5148
Last update 14 Mar 2026
Overview
Basic Info
Drug Type Monoclonal antibody |
Synonyms AZD-5148 |
Target |
Action inhibitors |
Mechanism toxB inhibitors(Toxin B inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Related
3
Clinical Trials associated with AZD5148NCT07285213
A Phase IIb, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of AZD5148 for Prevention of Recurrence of Clostridioides Difficile Infection in Individuals 18 Years of Age and Above
NCT06639997
A Phase I Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Japanese Adults
NCT06469151
A Phase I Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AZD5148 in Healthy Adults
100 Clinical Results associated with AZD5148
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100 Translational Medicine associated with AZD5148
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100 Patents (Medical) associated with AZD5148
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2
Literatures (Medical) associated with AZD514814 Nov 2025JOURNAL OF INFECTIOUS DISEASES
Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary
Clostridioides difficile
Isolates
Article
Author: Sellman, Bret R ; Green, Justin ; Tkaczyk, Christine ; Gamson, Adam ; Godfrey, Victoria ; Rosenthal, Kim ; Stanley, Ann Marie ; Brady, Tyler ; Gopalakrishnan, Vancheswaran ; Podlaha, Ondrej ; Nguyen, Emily ; Mahool, Kelly Ann
PLoS Pathogens
The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice
Article
Author: Cano Rodríguez, Rubén ; Knippel, Reece J ; Kordus, Shannon L ; Tkaczyk, Christine ; Peritore-Galve, F Christopher ; Shupe, John A ; Lacy, D Borden ; Kroh, Heather K ; Washington, M Kay ; Ehni, Alyssa G ; Stanley, Ann Marie ; Gamson, Adam
100 Deals associated with AZD5148
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Clostridium difficile infection | Phase 2 | United States | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Japan | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Australia | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Canada | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Denmark | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | France | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Germany | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Greece | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Hungary | 10 Dec 2025 | |
| Clostridium difficile infection | Phase 2 | Italy | 10 Dec 2025 |
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Biosimilar
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