Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. A previous small study has shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe, in asymptomatic carriers of malaria parasites. The current study will evaluate the efficacy and safety of the combination given for three days in children with uncomplicated malaria in Gabon.

Start Date01 Jun 2002

Sponsor / Collaborator

The Albert Schweitzer Fellowship

100 Clinical Results associated with Clindamycin phosphate/Fosmidomycin

100 Translational Medicine associated with Clindamycin phosphate/Fosmidomycin

100 Patents (Medical) associated with Clindamycin phosphate/Fosmidomycin

Literatures (Medical) associated with Clindamycin phosphate/Fosmidomycin

01 Jan 1989·Journal of Antimicrobial ChemotherapyQ2 · MEDICINE

Inhibition of bacterial isoprenoid synthesis by fosmidomycin, a phosphonic acid-containing antibiotic

Q2 · MEDICINE

Article

Author: Shigi, Y

The mechanism of action of fosmidomycin (FR-31564), a phosphonic acid containing antibiotic, was examined against Escherichia coli, Micrococcus luteus and other bacteria. It converted growing Esch. coli cells into spheroplasts or swollen cells, but did not inhibit the enzymatic reactions of cell wall synthesis in ether-treated cells. Unlike bicyclomycin, phenethyl alcohol and mitomycin C, it did not reduce the amount of envelope lipoprotein, phospholipids, or DNA, but did reduce the amount of menaquinones and ubiquinones in growing Esch. coli cells. It also inhibited the biosynthesis of both carotenoids and menaquinones in M. luteus cells, suggesting that inhibition of the biosynthesis of a common precursor of these isoprenoids (possibly farnesyl pyrophosphate) might be the main site of its antibacterial activity.

01 Oct 1982·Antimicrobial Agents and ChemotherapyQ2 · MEDICINE

Synergy of fosmidomycin (FR-31564) and other antimicrobial agents

Q2 · MEDICINE

Article

Author: Kamimura, Toshiaki ; Neu, Harold C.

Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin, and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37 to 52% of the Enterobacteriaceae tested. Synergy with trimethoprim was found against 55% of bacteria isolated, but only 17% of the strains showed synergy between formidomycin and gentamicin. Synergy between fosmidomycin and ticarcillin was shown for 35% of the Pseudomonas isolates. Cefazolin-, ampicillin-, and gentamicin-resistant isolates of various species were synergistically inhibited by fosmidomycin, as were ticarcillin- and gentamicin-resistant isolates. Antagonism was not encountered. This study illustrates another example of synergistic activity of compounds which attack different mechanisms in bacterial cells.

100 Deals associated with Clindamycin phosphate/Fosmidomycin

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Indication	Highest Phase	Country/Location	Organization	Date
Malaria	Phase 2	MZ	Jomaa Pharma GmbH	-
Malaria	Phase 2	-	-	-
Malaria	Discovery	-	-	-

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