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Last update 12 Apr 2025
Apocyanin
Last update 12 Apr 2025
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms Acetovanillone, apocynin |
Target |
Action inhibitors |
Mechanism NOX inhibitors(NADPH oxidase inhibitors) |
Therapeutic Areas |
Active Indication- |
Inactive Indication |
Originator Organization- |
Active Organization- |
Inactive Organization- |
Drug Highest PhasePendingPhase 1 |
First Approval Date- |
Regulation- |
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Structure/Sequence
Molecular FormulaC9H10O3 |
InChIKeyDFYRUELUNQRZTB-UHFFFAOYSA-N |
CAS Registry498-02-2 |
Related
8
Clinical Trials associated with ApocyaninCTIS2023-508791-11-00
A placebo-controlled, double-blinded, randomized, dose-finding trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
EUCTR2020-000249-14-DK
A placebo-controlled, double-blinded, randomized, trial using a combination of apocynin and paeonol (APPA) for the treatment of knee osteoarthritis
IRCT20200418047122N1
Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial
100 Clinical Results associated with Apocyanin
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100 Translational Medicine associated with Apocyanin
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100 Patents (Medical) associated with Apocyanin
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6,873
Literatures (Medical) associated with Apocyanin01 Jun 2025SEPARATION AND PURIFICATION TECHNOLOGY
Catalytic oxidative depolymerization of lignin to aromatic compounds using transition metal doped ionic Liquid-based polyoxometalate catalysts
Author: Shi, Junyou ; Zhao, Luyao ; Zhang, Yu ; Deng, Haoyu ; Xu, Wenbiao ; Li, Mingfei
Significant attention has been focused on the depolymerization of lignin into monophenolics, as lignin is the most abundant biomass feedstock, and its valorization is considered crucial for a complete biomass refinery.In this study, we investigate catalytic oxidative depolymerization using novel bimetallic transition metal (Ni and Co) doped ionic liquid-polyoxometalate (ILPOM) composites under aerobic conditions.We systematically evaluate various catalysts, including [MIMPS]H2PW12O40, Ni[MIMPS]PW12O40, Co[MIMPS]PW12O40, [MIMPS]H2PMo12O40, Ni[MIMPS]PMo12O40, and Co[MIMPS]PMo12O40, assessing their impact on monomer yield and selectivity.Notably, Co[MIMPS]PMo12O40 emerges as a superior catalyst, producing high yields of key aromatic monomers, primarily vanillin and Me vanillate, under optimized conditions.Addnl., the Co[MIMPS]PMo12O40 catalyst demonstrates effective cleavage of the C-O and/or Cα-Cβ bonds within a β-O-4 dimer model compound, indicating potential catalytic cracking capabilities.This investigation elucidates the intricate interplay among transition metals, ionic liquids (ILs), and lignin, providing a novel pathway for lignin transformation.
01 May 2025FUEL
The integrated process of CO2 reforming of methane with co-pyrolysis of Naomaohu coal and elm to improve tar yield
Author: Jin, Lijun ; Dai, Zhenghua ; Zhong, Mei ; Luo, Jie ; Liu, Yang
Co-pyrolysis of coal and biomass is an effective route to replace coal utilization with alternative biomass resource.However, it is crucial to acquire high tar yield during co-pyrolysis.To improve tar yield during co-pyrolysis of Naomaohu coal and elm, in this work, a new process was constructed by integrating co-pyrolysis with CO2 reforming of methane over 10Ni/γ-Al2O3 catalyst (CP-CRM) on an IR-heated fixed-bed reactor, and the effect of pyrolysis temperatures on the integrated process was investigated.The comparison of co-pyrolysis behaviors under N2 (CP-N2) or CH4/CO2 (CP-CH4/CO2) atm. was conducted to reveal the reaction mechanism during CP-CRM.Result revealed that the CP-CRM showed higher tar yield than co-pyrolysis under CP-N2, and the maximum tar yield of 21.68 wt% was achieved at 500 °C during the integrated process, which was 1.13 times as that under CP-N2.In comparison, tar yield in co-pyrolysis under CH4/CO2 mixture gas was between those of CP-N2 and CP-CRM, indicating that CH4 and CO2 themselves could facilitate the formation of tar, which could further be strengthened under the action of 10Ni/γ-Al2O3 catalyst.The analyses of co-pyrolysis tar by simulated distillation, GC/MS, 1H-NMR and 13C-NMR showed that the pitch content in co-pyrolysis tar from CP-CRM was higher than those in CH4/CO2 and N2 atmospheres, and high phenols content up to 60.05 % was obtained, higher than 51.61 % in tar from CP-N2.Addnl., the tar from CP-CRM possessed more aromatics with short side chains compared than those from pyrolysis under N2 and CH4/CO2, which was mainly ascribed to the participation of active free radicals from CO2 reforming of CH4.This work provides a simple route to improve tar yield and phenols content in tar during co-pyrolysis.
01 Apr 2025FOOD CHEMISTRY
Non-targeted analysis using gas chromatography mass spectrometry to assess the free and bound aroma fingerprints of the emblematic Greek white winegrape varieties and guarantee varietal authenticity using multivariate chemometrics
Article
Author: Gkrimpizis, Theodoros ; Kalogiouri, Natasa P ; Ouroumi, Niki-Athina ; Karadimou, Christina ; Menkissoglu-Spiroudi, Urania ; Chatzidimitriou, Effimia ; Theocharis, Serafeim ; Koundouras, Stefanos
A non-targeted analytical approach using gas chromatography-mass spectrometry (GC-MS) is proposed for the analysis of the free and bound volatile fractions of three emblematic indigenous Greek white winegrape varieties belonging to Vidiano, Malagousia, and Savvatiano and establish volatile varietal markers using multivariate chemometrics. A total of 89 free and 103 bound volatile compounds were identified, categorized into alcohols, aldehydes, esters, acids, terpenes, norisoprenoids, C6 compounds, phenols, and ketones. A robust Partial Least Squares Discriminant Analysis (PLS-DA) prediction model was developed and validated, and successfully classified the grape samples according to the variety with 100 % accuracy, demonstrating the potential of volatile profiling as a non-targeted fingerprinting approach for varietal discrimination. Malagousia variety exhibited the highest concentration of terpenes, particularly in the bound fraction, highlighting its intense floral character. The proposed analytical workflow was successfully applied for the investigation of the unique aroma profiles of Greek white winegrape varieties. The findings contribute to the understanding of unique volatile fingerprints of the winegrape varieties and support the adaptation of vineyard and winery practices to enhance their varietal expression.
2
News (Medical) associated with Apocyanin16 Jan 2024
Clinical ResultPhase 2Phase 1
100 Deals associated with Apocyanin
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Atherosclerosis | Phase 1 | - | - | - |
| Diabetic Neuropathies | Phase 1 | - | - | - |
| Hypertension | Phase 1 | - | - | - |
| Inflammatory Bowel Diseases | Phase 1 | - | - | - |
| Parkinson Disease | Phase 1 | - | - | - |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Not Applicable | - | - | mleluoulaf(ahzvapzeiq) = necddnncfn rtuvskrznp (diffebyfky ) | Positive | 05 Jun 2024 | ||
bssdoixhmz(jzvbparyjo) = zxdbjpdblk eudyidyrui (mfluokifml ) View more | |||||||
Not Applicable | - | Apocynin and paeonol (APPA) | tfyfgfsnnt(erichccijk) = tlsnlqowvw mmfespagzd (wemwprzgug ) | Positive | 03 Jun 2020 | ||
Not Applicable | - | - | AN-1 | mxfppuctsb(tarmkoiaac) = pujxmcozcs iezxaqfowd (kwgrsnpibh ) View more | - | 30 Jul 2013 | |
mxfppuctsb(tarmkoiaac) = ciuqrmynbn iezxaqfowd (kwgrsnpibh ) View more | |||||||
Not Applicable | Hypertension reactive oxygen species (ROS) | - | rbtmqemkng(wltiklvpnn) = ybhmxzfkft cjwjvoeqtm (ozdwboanny ) View more | Positive | 01 Sep 2012 | ||
rbtmqemkng(wltiklvpnn) = tpiiuasfgv cjwjvoeqtm (ozdwboanny ) | |||||||
Not Applicable | - | - | vskaodtiwu(vsjfmxizsf) = xxkmrghaig mnfsjcqaze (ebwhwqgwry ) View more | - | 01 Sep 2011 | ||
Not Applicable | 14 | iptzcssopu(njcxtxzmiz) = wrybcbcusz iurgrryvca (kldnqponka ) View more | Positive | 01 Sep 2011 | |||
Placebo | iptzcssopu(njcxtxzmiz) = cyomllpipe iurgrryvca (kldnqponka ) View more | ||||||
Not Applicable | - | - | eqzbdrtxkc(rnbtjvoiej) = ziengjvrnx gfpdjvfvbm (wjbfnvjdpi ) View more | - | 01 Sep 2011 | ||
Placebo | eqzbdrtxkc(rnbtjvoiej) = aznqicprjx gfpdjvfvbm (wjbfnvjdpi ) View more |
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