A 75-year-old woman was admitted after suffering from acute sciatica for 2 days. The symptoms consisted of numbness and neurological pain disseminating from the lumbarsacral region with radiation to the lower right limb. Her blood pressure was 124/78 mmHg, body temperature 37°C, pulse rate 72 beats/min and respiratory rate 18 breaths/min. On examination, tenderness of the lumbar-sacral spine was noted with right neurological deficiency and decreasing degrees of straight leg raising test. Laboratory data showed a white blood cell count of 9100/μL, and C-reactive protein 0.41 mg/dL. A magnetic resonance image (MRI) of the L-spine revealed a mass lesion over the right S1 root, involving the vertebral pedicle (Figure 1). A diagnosis of malignancy or infection was highly suspected. Surgical biopsy was suggested. However, prior to the biopsy, painful erythematous grouped vesicles were observed on the right posterolateral region of the thigh (Figure 2a). Subsequently, herpes zoster disseminated to the optic division and trunk. After consulting a dermatologist, the lesion was suspected to be herpes zoster virus infection. The diagnosis was confirmed by clinical symptoms, positive for serum Varicella-zoster virus (VZV), IgM antibody and a Tzanck smear test (Figure 2b). After therapy with acyclovir 250 mg, 3 times per day and wet dressings of postgrouped vesicles, pain and skin eruption gradually improved. We were unable to confirm the cutaneous herpes zoster without having definite verification for the cause of the extraspinal lesion. A percutaneous transpedicular biopsy was performed to exclude malignancy. Histopathology of the specimen revealed acute inflammation without malignancy (Figure 3). It was compatible with herpes zoster infecting the nerve, hence presenting acute sciatica. The patient received anti-herpes zoster virus drug therapy and her symptoms of acute sciatica improved.

100 Deals associated with Anti-varicella-zoster virus antibody(Beijing Zhiren Meibo)

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Indication	Highest Phase	Country/Location	Organization	Date
Varicella Zoster Virus Infection	Discovery	China	Beijing Zhiren Meibo Biotechnology Co., Ltd.	15 Sep 2022

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Anti-varicella-zoster virus antibody(Beijing Zhiren Meibo)

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