Delving into the Latest Updates on Captopril/Hydrochlorothiazide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Compound Captopril, 卡托普利/氢氯噻嗪, Capozide

+ [2]

Target

ACE x NCC

Mechanism

ACE inhibitors(Angiotensin-converting enzyme inhibitors), NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors)

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Hypertension

Inactive Indication-

Originator Organization

Bristol Myers Squibb Co.

Active Organization

Changzhou Pharmaceutical Factory Co., Ltd.

Inactive Organization

Apothecon LLC

Drug Highest PhaseApproved

First Approval Date

US (12 Oct 1984),

Hypertension

Regulation-

Login to view timeline

Structure

Molecular FormulaC16H23ClN4O7S3

InChIKeySFIUYASDNWEYDB-HHQFNNIRSA-N

CAS Registry110075-07-5

Several surveys had revealed that Tibetan adults had high prevalence of hypertension. However, there was no research studying the antihypertensive effect of the known drugs in Tibetan. The main arms of our study were to determine if the efficacy of lowing blood pressure and protecting target organ damage differs between nitrendipine and Hydrochlorothiazide in mild hypertension in Tibetan, and to determine if the efficacy of lowing blood pressure and protecting target organ damage differs between captopril plus Hydrochlorothiazide and Beijing hypotensive No.0 in moderate and severe Tibetan hypertension.

Start Date01 Aug 2014

Sponsor / Collaborator

West China Hospital

100 Clinical Results associated with Captopril/Hydrochlorothiazide

Login to view more data

100 Translational Medicine associated with Captopril/Hydrochlorothiazide

Login to view more data

100 Patents (Medical) associated with Captopril/Hydrochlorothiazide

Login to view more data

16

Literatures (Medical) associated with Captopril/Hydrochlorothiazide

01 Jan 2005·KardiologiiaQ4 · MEDICINE

[Comparative efficacy of fixed dose combinations of enalapril with hydrochlorothiazide and captopril with hydrochlorothiazide in patients with high risk hypertension].

Q4 · MEDICINE

Article

Author: Nedogoda, S V

Clinical effectiveness and tolerability of o.d. use of fixed dose combinations of enalapril (10 mg) with hydrochlorothiazide (25 mg) (Enap H) and captopril (50 mg) with hydrochlorothiazide (25 mg) (Capozide) were compared in a randomized study on 60 patients with I-II degree high and very high risk hypertension. Study duration was 6 months, number of patients in each of parallel groups -- 30. Antihypertensive activity, ability to improve arterial elasticity and T/P parameter, cost/efficacy index of enalapril (10 mg) plus hydrochlorothiazide (25 mg) combination was found to be superior to those of captopril (50 mg) plus hydrochlorothiazide (25 mg) combination.

01 Jan 2005·KardiologiiaQ4 · MEDICINE

[Comparative efficacy of fixed dose combinations of perindopril with indapamide and captopril with hydrochlorothiazide in patients with high risk hypertension].

Q4 · MEDICINE

Article

Author: Marchenko, I V ; Prokhorova, E A ; Nedogoda, S V ; Brel', U A ; Tsoma, V V ; Chaliabi, T A

Clinical effectiveness and tolerability of o.d. use of fixed dose combinations of perindopril (4 mg) with indapamide (1.25 mg) (Noliprel forte) and captopril (50 mg) with hydrochlorothiazide (25 mg) (Capozide) were compared in a randomized study on 40 patients with I-II degree high and very high risk hypertension. Study duration was 6 months, number of patients in each of parallel groups -- 20. Antihypertensive activity, ability to decrease left ventricular hypertrophy, to improve arterial elasticity and T/P parameter of perindopril (4 mg) -- indapamide (1.25 mg) combination was found to be superior to those of captopril (50 mg) -- hydrochlorothiazide (25 mg) combination.

01 Jun 2000·European Journal of Drug Metabolism and PharmacokineticsQ4 · MEDICINE

Liquid extraction and HPLC-DAD assay of hydrochlorothiazide from plasma for a bioequivalence study at the lowest therapeutic dose

Q4 · MEDICINE

Article

Author: V. David ; D. S. Miron ; C. Mircioiu ; A. Medvedovici

The main parameters considered in optimizing the liquid extraction and quantitative assay were the yield, precision, limit of quantification, time required for extraction and concentration, and quantity of solvent. The influence on these parameters of the following factors was examined: nature of the extracting solvent, quantity of solvent, co-extraction solvent, and duration of stirring. Instead of equilibrium parameters of the involved thermodynamic system, a kinetic approach was preferred in terms of the effective partition 'constant', which is not really constant but a function of time and extraction conditions. The final selected method, considered to be rapid and simple, was applied to determine the pharmacokinetics of hydrochlorotiazide (HCT) after administration of Capozide (Bristol-Myers Squibb) tablets containing 50 mg Captopril and 25 mg HCT, to 4 healthy volunteers. The results obtained were in accordance with the pharmacokinetic parameters of HCT reported in the literature.

100 Deals associated with Captopril/Hydrochlorothiazide

Login to view more data