Compound54(IMPACT Therapeutics)

A review.This study evaluated the influences on mitochondrial morphol. and cell growth in wild-type and mutant strains of arylthioindole 24 and pyrrole derivative 54, the latter designed by replacing indole nucleus with pyrrole ring.It was confirmed that the cytotoxicity of compound 54 is not related to the polymerization of tubulin.The toxicity of compound 24, observed in the wild type, might be linked to mitochondrial dynamics while, in the case of compound 54, which does not alter the mitochondrial network, toxicity might be associated to the induction of apoptosis.Generally, it was found that compound 24 induces mitochondrial fragmentation and triggers apoptosis, while compound 54 can still induce apoptosis through an unknown pathway.The results demonstrated the importance of using yeast as a model system for exploring the potential new therapeutic mols. and encourage the hope of getting new anticancer agents.