Cyclophosphamide is a drug used in chemotherapy. However, it has side effects, including changes in reproductive system functioning. Some herbal compounds can reduce the harmful effects of cyclophosphamide. This study aims to investigate the protective role of crocin against changes caused by Cyclophosphamide in ovarian tissue through changes in the expression of genes involved in the hypothalamic-pituitary-gonadal axis. This experimental study was performed on 24 adult female Wistar rats. Mice were divided into four groups (normal saline, 30 mg/kg cyclophosphamide, 100 mg/kg crocin and 30 mg/kg cyclophosphamide, and 200 mg/kg crocin and 30 mg/kg cyclophosphamide). At the end of the treatment period, the hypothalamus and ovaries were also removed to evaluate ob-Rb, ob-Ra, and NPY genes expression using real-time PCR and histological changes in the ovaries. Data were analyzed by SPSS statistical software. The expression of genes, number of follicles, and follicle diameter significantly decreased in the cyclophosphamide-treated groups compared with the control group. In the crocin and cyclophosphamide-treated groups, drug-induced reproductive complications were mitigated. The current findings indicate that by increasing the expression of genes ob-Rb, ob-Ra, and NPY, crocin could modulate the harmful effects of cyclophosphamide.

01 Jan 2022·Journal of ProsthodonticsQ3 · MEDICINE

Selective Laser Melted Titanium Alloy for Transgingival Components: Influence of Surface Condition on Fibroblast Cell Behavior

Q3 · MEDICINE

Article

Author: Fromentin, Olivier ; Rohman, Géraldine ; Guilbert, Thomas ; Attal, Jean‐Pierre ; Crenn, Marie‐Joséphine ; Benoit, Aurélie ; Bardet, Claire

AbstractPurposeTo mechanically characterize and assess the biological properties of Ti6Al4V surfaces obtained by Selective Laser Melting in order to determine whether this process is conceivable for production of implant‐supported prostheses and particularly trans‐gingival components. As‐built and polished surfaces were studied in comparison with components obtained by computer numerical control machining technology in order to consider whether the properties are in the same range as the conventional method currently used.Materials and MethodsCylindrical specimens of Ti6Al4V (n = 6) were built with Selective Laser Melting for the characterization of mechanical properties according to ISO 22674 and discs (n = 12) were fabricated in the same conditions for cytotoxicity evaluation. Discs (n = 12) of Ti6Al4V were also obtained by computer numerical control machining as control. Half of the number of discs (n = 6) from each process were polished, to simulate the laboratory protocol for polishing of transmucosal components and half of the discs remained unaltered (as‐built). Surface roughness measurements of disc specimens (as‐built and polished) were compared with computer numerical control milling specimens (as‐built and polished). Proliferation of human gingival fibroblasts on Ti6Al4V surfaces was also assessed for each condition. Viability and cell morphology were then evaluated qualitatively. Ra and Sa data were compared using Student's t‐test (α = 0.05) and metabolic activity data were compared using Kruskal‐Wallis statistical test (α = 0.05).ResultsSelective Laser Melting specimens showed elongation at break greater than 2% and 0.2% yield strength better than 500MPa which complied with ISO 22674 standards. Although Selective Laser Melting samples displayed significantly increased roughness on as‐built surfaces compared to computer numerically controlled milling samples (p < 0.05), no statistically significant difference was observed after mechanical polishing (p = 0.279). Regarding metabolic activity, no statistical difference was observed between groups at day 3 (p > 0.05) and fibroblasts showed a viability higher than 97% on all discs. Cell shapes on polished samples suggested moderate adhesion compared to unpolished samples.ConclusionWith the manufacturing parameters selected in this study, Selective Laser Melting of Ti6Al4V appeared to be compatible with a prosthetic application type 4 according to ISO 22674. Surfaces obtained, followed by recommended postprocessing provided components with equivalent biological properties compared to computer numerical control machining technology.

27 Jun 2021·Orvosi HetilapQ4 · MEDICINE

A vesetranszplantáció korai posztoperatív hatásai a szív- és érrendszeri betegségekre klinikai gyakorlatunkban

Q4 · MEDICINE

Article

Author: Szabó, Eszter ; Nemes, Balázs ; Szőllősi, Gergő József ; Daragó, Andrea ; Barkó, Dorina ; P. Szabó, Réka ; Nagy, Attila Csaba ; Schwegler, Gerda

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COG ANBL0032 (ASCO2004)	Phase 3	High Risk Neuroblastoma	27	13-cis-retinoic acid (RA)	dhvttzqfeq(fnzbkrkqfs) = twrpsucszx dojdilbddm (rscjmmnhky ) View more	-	15 Jul 2004
COG ANBL0032 (ASCO2004)	Phase 3	High Risk Neuroblastoma	27	RA + immunotherapy with 5 courses of Ch14.18 and alternating cycles of GM-csf and IL2	dhvttzqfeq(fnzbkrkqfs) = gcqxknzwds dojdilbddm (rscjmmnhky ) View more	-	15 Jul 2004
ASCO2004	Phase 2	Metastatic Colorectal Carcinoma Maintenance	20	IL-2 and RA	(suqzpkjdtr) = rtmykchmwg fxvgymjdhr (ljwacwenwj ) View more	-	15 Jul 2004

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