Last update 21 Nov 2024

Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Monosodium acetate trihydrate/Potassium Chloride/Calcium Chloride Hydrate /Sodium Chloride, Acetated Ringer'S In Plastic Container, SOLYU － GEN

+ [1]

Target-

Mechanism-

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Acidosis

Inactive Indication-

Originator Organization

B. Braun Medical, Inc.

Active Organization

neo CritiCare Phama Co., Ltd.

Inactive Organization

B. Braun Medical, Inc.

Drug Highest PhaseApproved

First Approval Date

US (29 Nov 1982)

Regulation-

Structure

Molecular FormulaClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS Registry7647-14-5

View All Structures (4)

Clinical Trials associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

PACTR201711002708423 / Unknown statusNot ApplicableIIT

Comparison of endothelial cell changes by specular microscopy between Ringer¿s and Ringers Lactate during Phacoemulsification

Start Date01 May 2017

Sponsor / Collaborator

The Authors Guild

100 Clinical Results associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

100 Translational Medicine associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

100 Patents (Medical) associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

Literatures (Medical) associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

01 Mar 2021·Annals of Translational MedicineQ4 · MEDICINE

Bicarbonate Ringer’s solution for early resuscitation in hemorrhagic shock rabbits

Q4 · MEDICINE

Article

Author: Mi, Weidong ; Lou, Jingsheng ; Liu, Jing ; Wang, Tao ; Wang, Long ; Cao, Jiangbei

BACKGROUNDFluid resuscitation is important for correcting hypovolemia. Isotonic crystalloids are the preferred solution for the initial clinical management of patients with multiple traumas. Bicarbonated Ringer's solution (BRS), offering physiological levels of bicarbonate ions and electrolyte ions, can be used for supplementing missing extracellular fluid and correcting metabolic acidosis. We here investigated the effects of BRS on the resuscitation of hemorrhagic shock models and compared the resuscitation performance of three crystalloids, including BRS, acetated Ringer's solution (ARS), and normal saline.METHODSThirty adult male New Zealand rabbits were randomly divided into five groups (n=6): a sham operation group (Sham group), an operation without fluid therapy group (Shock group), a BRS group, an ARS group, and a normal saline group (Saline group). The New Zealand rabbits experienced rapid bloodletting to shock status and maintained for 20 minutes except Sham group. The status of shock was maintained in the Shock group. The fluid was infused at a rate of 60 mL/kg per hour for 1.5 hours in three fluid therapy group. Measurement of vital signs, arterial blood gas tests, blood biochemistry, hematoxylin and eosin (HE) staining of lung tissue, TUNEL staining of the liver and kidney tissues, and analysis of intestinal flora were performed.RESULTSThe reduction in both base excess (BE) and bicarbonate ion (HCO₃ ^-) caused by acidosis in rabbits with hemorrhagic shock was significantly improved in the BRS group when compared with the Saline group at infusion for 30 minutes (T3) and 30 minutes after infusion (T5) (BRS group vs. Saline group, BE: at T3, -4.83±3.60 vs. -12.50±3.27 mmol/L, P<0.01; at T5, -3.67±4.37 vs. -11.00±2.76 mmol/L, P<0.01; HCO₃ ^-: at T3, 22.15±2.63 vs. 15.42±3.03 mmol/L, P<0.01; at T5, 23.15±2.9 vs. 16.23±3.07 mmol/L, P<0.01). Compared with Shock group, liver cell apoptosis due to hemorrhagic shock was relieved in both the BRS group and ARS group (BRS group vs. Shock group: 19.1±3.3 vs. 28.1±6.1, P<0.05; ARS group vs. Shock group: 19.8±5.4 vs. 28.1±6.1, P<0.05).CONCLUSIONSDuring resuscitation of hemorrhagic shock, BRS, a novel perioperative balanced crystalloid, is more effective than normal saline in maintaining acid-base balance and in protecting tissues and organs.

01 Sep 2018·PerfusionQ4 · MEDICINE

Is the use of hydroxyethyl starch as priming solution during cardiac surgery advisable? A randomized, single-center trial

Q4 · MEDICINE

Article

Author: Kvalheim, Venny L. ; Mongstad, Arve ; Haaverstad, Rune ; Farstad, Marit ; Svendsen, Øyvind S. ; Husby, Paul

Introduction: The use of cardiopulmonary bypass (CPB) leads to increased fluid filtration and edema. The use of artificial colloids to counteract fluid extravasation during cardiac surgery is controversial. Beneficial effects on global fluid loading, leading to better cardiac performance and hemodynamics, have been claimed. However, renal function and coagulation may be adversely affected, with unfavorable impact on outcome following cardiac surgery. Methods: Forty patients were randomly allocated to study groups receiving either acetated Ringer’s solution (CT group) or hydroxyethyl starch (HES group, Tetraspan®) as CPB priming solution. Fluid balance, bleeding and hemodynamics, including cardiac output, were followed postoperatively. The occurrence of acute kidney injury was closely registered. Results: Two patients were excluded from further analyzes due to surgical complications. Fluid accumulation was attenuated in the HES group (3374 (883) ml) compared with the CT group (4328 (1469) ml) (p=0.024). The reduced perioperative fluid accumulation was accompanied by an increased cardiac index immediately after surgery (2.7 (0.4) L/min/m2 in the HES group and 2.1 (0.3) L/min/m2 in the CT group (p<0.001)). No increase in bleeding could be demonstrated in the HES group. Three patients, all of them in the HES group, experienced acute kidney injury postoperatively. Conclusions: CPB priming with HES solution lowers fluid loading during bypass and improves cardiac function in the early postoperative period. The manifestation of acute kidney injury exclusively in the HES group of patients raises doubts about the use of HES products in conjunction with cardiac surgery. ( https://clinicaltrials.gov/ct2/show/NCT01511120 )

01 May 2016·Acta Anaesthesiologica ScandinavicaQ4 · MEDICINE

Distribution of crystalloid fluid changes with the rate of infusion: a population‐based study

Q4 · MEDICINE

Article

Author: Drobin, D. ; Zdolsek, J. ; Hahn, R. G.

BackgroundCrystalloid fluid requires 30 min for complete distribution throughout the extracellular fluid space and tends to cause long‐standing peripheral edema. A kinetic analysis of the distribution of Ringer′s acetate with increasing infusion rates was performed to obtain a better understanding of these characteristics of crystalloids.MethodsData were retrieved from six studies in which 76 volunteers and preoperative patients had received between 300 ml and 2375 ml of Ringer's acetate solution at a rate of 20–80 ml/min (0.33–0.83 ml/min/kg). Serial measurements of the blood hemoglobin concentration were used as inputs in a kinetic analysis based on a two‐volume model with micro‐constants, using software for nonlinear mixed effects.ResultsThe micro‐constants describing distribution (k12) and elimination (k10) were unchanged when the rate of infusion increased, with half‐times of 16 and 26 min, respectively. In contrast, the micro‐constant describing how rapidly the already distributed fluid left the peripheral space (k21) decreased by 90% when the fluid was infused more rapidly, corresponding to an increase in the half‐time from 3 to 30 min. The central volume of distribution (Vc) doubled.ConclusionThe return of Ringer′s acetate from the peripheral fluid compartment to the plasma was slower with high than with low infusion rates. Edema is a normal consequence of plasma volume expansion with this fluid, even in healthy volunteers. The results are consistent with the view that the viscoelastic properties of the interstitial matrix are responsible for the distribution and redistribution characteristics of crystalloid fluid.

100 Deals associated with Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Acidosis	JP	neo CritiCare Phama Co., Ltd.	15 Mar 1996

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Calcium Chloride/Potassium Chloride/Sodium Acetate/Sodium Chloride

Overview

Basic Info

Structure

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation