Inhibition of dissolution of calcium hydroxyapatite in the presence of bendroflumethiazide, Centyl, and of hydrochlorothiazide has been investigated. The former compound has a pronounced larger inhibitory effect than the latter. The trifluormethyl group in bendroflumethiazide has been shown to hydrolyze, with the release of fluoride and hydrogen ions, presumably forming a carboxylic acid. The inhibitory effect of hydrolyzed bendroflumethiazide is found to be similar to the effect of a potassium fluoride solution with the same fluoride ion concentration, as measured by a fluoride selective ion electrode.

12 Jan 1973·Acta Medica Scandinavica

THE EFFECT OF BENDROFLUMETHIAZIDE ON THE RENAL HANDLING OF CALCIUM, MAGNESIUM AND PHOSPHATE IN NORMOCALCAEMIC RENAL STONE FORMERS AND IN HYPERPARATHYROIDISM

Article

Author: Transbol I ; Jorgensen Fs

Abstract. The effect of bendroflumethiazide (Centyl®) on the renal excretion of calcium, magnesium and phosphate has been investigated in 10 normocalcaemic renal stone formers and 10 hyperparathyroid patients to evaluate the effect of diuretic thiazides on calcium metabolism. A significant increase in the tubular reabsorption of calcium and a significant decrease in the tubular reabsorption of magnesium were observed in both groups. A reduction of 52% in renal calcium excretion was found in both groups, being independent of supposed differences in parathyroid hormone secretion but significantly related to the pretreatment urinary calcium excretion. The renal excretion of magnesium and phosphate increased during thiazide administration. Different theories concerning the mechanisms through which diuretic thiazides act on calcium metabolism are discussed. Based on the present results combined with previous investigations, both a direct effect on tubular calcium reabsorption and an effect on bone metabolism are postulated.

01 Jul 1972·Acta Pharmacologica et Toxicologica

Effect of a Single, Large Intramuscular Dose of Bendroflumethiazide (Centyl®) on Calcium Metabolism in Rats

Article

Author: F S Jorgensen

A single, large dose of bendroflumethiazide was given intramuscularly in rats to investigate a possible extrarenal effect on calcium metabolism. Neither in normal, parathyroidectomized, thyroidectomized or thyro‐para‐thyroidectomized rats nor by concomitant nephrectomy or parathyroid hormone administration, could any effect of bendroflumethiazide on the serum calcium concentration be demonstrated. The present findings are discussed in relation to previous experiments done in dogs and human subjects which suggested either a stimulating effect on the parathyroid glands or a potentiating effect of the thiazides on the action of the parathyroid hormone.

100 Deals associated with Bendroflumethiazide/Potassium Chloride

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Indication	Country/Location	Organization	Date
Edema	SE	Karo Healthcare AB	17 Sep 2010
Hypertension	SE	Karo Healthcare AB	17 Sep 2010
Nephrolithiasis	SE	Karo Healthcare AB	17 Sep 2010

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