A double blinded, randomised controlled trial to determinea) the efficacy of alpha-cyclodextrin on cholesterol control, andb) the efficacy of Compound K on glycaemic controlin overweight and obese participants with pre-diabetes.

Start Date01 Jul 2015

Sponsor / Collaborator

The University of Sydney

100 Clinical Results associated with ASD-004 (ASDERA)

100 Translational Medicine associated with ASD-004 (ASDERA)

100 Patents (Medical) associated with ASD-004 (ASDERA)

314

Literatures (Medical) associated with ASD-004 (ASDERA)

01 Feb 2025·Carbohydrate Research

2A,6A−F-Hepta-O-tert-butyldimethylsilyl α-cyclodextrin – A carbohydrate undecaol with all OH groups visible in NMR indicative of a partially disrupted hydrogen bond network

Article

Author: Bols, Mikael ; Zimmermann, Morten Lang

During a synthesis of the well-known and useful building block 6^A-F-hexa-O-tert-butyldimethylsilyl α-cyclodextrin (2) by silylation of α-cyclodextrin (1) we isolated as a byproduct the oversilylated 2^A,6^A-F-hepta-O-tert-butyldimethylsilyl α-cyclodextrin (3) where one 2-OH group has also been silylated. This unsymmetrical new compound has a remarkable ¹H NMR spectrum in CDCl₃ where all 11 alcohol groups are visible. We have analyzed the spectrum of 3 using 1D and 2D 800 MHz NMR and are able to assign all the 11 alcohol protons. The remarkable chemical shifts of these protons are interpreted as being due to a partial disruption of an otherwise efficient hydrogen bond network.

01 Dec 2024·The Journal of Nutrition

The Soluble Fiber α-Cyclodextrin and the Fecal Losses of Dietary Fat in Adults – A Double Blind, Randomized, Placebo-Controlled, Crossover Study

Letter

Author: Artiss, Joseph D ; Artiss, Joseph D. ; Catherine Jen, Kai-Lin ; Jen, Kai-Lin Catherine

Effects of alpha-Cyclodextrin (alpha-CD), a soluble dietary fiber on fecal losses of dietary fat as well as blood lipid and glucose concentrations following a meal containing radiolabeled triglyceride (TG).By using NMR to measure total fecal fat.Total fecal fat content and radiotracer appearance in postprandial plasma TGs did not differ between the α-CD and placebo treatments.

01 Dec 2024·Food Chemistry

Alpha-cyclodextrin increases glucagon-like peptide-1 secretion in multiple models and improves metabolic status in mice

Article

Author: Drzazga, Anna Katarzyna ; von Voss, Liv ; Smits, Mark M ; Beaman, Emily Eufaula ; Holst, Jens Juul ; Rosenkilde, Mette Marie ; Brethvad, Annemette Overgaard

Alpha-cyclodextrin (α-CD) is a non-absorbable and soluble fiber that causes weight loss. We studied whether this is due to an effect on GLP-1 secretion. In GLUTag cells, α-CD increased GLP-1 secretion up to 170% via adenylyl cyclase, phospholipase C, and L-type calcium channels dependent processes. In rat isolated colon perfusions, luminal α-CD increased GLP-1 secretion with 20%. In lean mice, once daily α-CD versus saline caused weight loss and lowered the peak in glucose after an oral glucose tolerance test (OGTT). In obese mice, α-CD added to high-fat diet caused weight loss similar to the control group (receiving cellulose). However, compared to cellulose, the α-CD group ate less. During an OGTT, no differences were observed in glucose, insulin and GLP-1. Thus, α-CD increases GLP-1 secretion in a dose-dependent manner and could be a safe and easy addition to food products to help reduce body weight.

100 Deals associated with ASD-004 (ASDERA)

External Link

KEGG	Wiki	ATC	Drug Bank
-	ASD-004 (ASDERA)	-	DB01909

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Indication	Highest Phase	Country/Location	Organization	Date
Metastatic breast cancer	Discovery	US	Asdera LLC	-
Metastatic Prostate Carcinoma	Discovery	US	Asdera LLC	-

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