Delving into the Latest Updates on Bendazac Lysine with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Bendazac lysine (BAN), Bendalina

Target

AKR1B1

Action

inhibitors

Mechanism

AKR1B1 inhibitors(Aldose reductase inhibitors)

Therapeutic Areas

Eye DiseasesEndocrinology and Metabolic DiseaseUrogenital Diseases

Active Indication

CataractDiabetic Nephropathies

Inactive Indication-

Originator Organization

Zhejiang Shapuaisi Pharmaceutical Co. Ltd.

Active Organization

Zhejiang Shapuaisi Pharmaceutical Co. Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC22H28N4O5

InChIKeyOCOCFNMFLNFNIA-ZSCHJXSPSA-N

CAS Registry81919-14-4

View All Structures (2)

AbstractDecarboxylative alkylation of carboxylic acids with easily oxidizable functional groups such as phenol and indole functionalities was achieved using a catalytic amount of basic iron(III) acetate, Fe(OAc)2(OH), in the presence of benzimidazole under 427 nm LED irradiation. Kinetic analyses of this catalytic reaction revealed that the reaction rate is first‐order in alkenes and is linearly correlated with the light intensity; the faster reaction rate for the benzimidazole‐ligated species was consistent with the increased absorbance in the visible light region. Wide functional group tolerance for the easily oxidizable groups is ascribed to the weak oxidation ability of the in situ‐generated oxo‐bridged iron clusters compared with other iron(III) species.

01 Jun 2024·ChemPhotoChem

Hydrodifluoromethylation of unactivated alkenes enabled by Visible‐Light Photocatalysis

Author: Yatham, Veera Reddy ; Kumar, Vivek ; Perumandla, Sanjay Kumar ; Jha, Avishek Kumar

AbstractIn the present manuscript, we have reported a general catalytic strategy that allows the synthesis of a variety of difluoro methylated alkanes from the corresponding unactivated alkenes using commercially available radical difluoromethylating reagent (CF2HSO2Na) under visible light photocatalysis. Further, this strategy allows the late‐stage modification of various alkenes derived from pharmaceutically relevant drugs.

01 Mar 2024·Chem Catalysis

Chemoselective direct deuterodecarboxylation of free aliphatic carboxylic acids enabled by deuteron-coupled electron transfer

Author: Deng, Jin ; Wang, Guang-Zu ; Fu, Yao ; Luo, Jia-Hao ; Xu, Yuantai ; Deng, Chen-Qiang

Decarboxylative deuteration of activated precursors (e.g., α-amino acids) is an effective method for installing deuterium atoms at activated positions; however, direct usage of unactivated aliphatic carboxylic acids remains a long-standing challenge for the construction of C(sp³)-D bonds at non-activated positions.Herein, we report a general and efficient photoinduced direct deuterodecarboxylation of free aliphatic carboxylic acids via synergistic acridine and thiophenol catalyst systems with D₂O as the cost-effective deuterium source, achieving precise installation of a deuterium atom at non-activated positions.The present methodol. features broad functional group tolerance and displays high chemoselectivity, enabling the late-stage deuteration of natural products and pharmaceuticals, with high levels of D-incorporation (up to 90 examples, up to 99% D).Moreover, a 50 mmol scale-up reaction in the continuous flow process has been demonstrated without loss of D-incorporation and greatly improves the production efficiency with a shortened reaction time from 12 h to 15 min.

100 Deals associated with Bendazac Lysine

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