Roseomonas mucosa(NIAID)

Background:
Atopic dermatitis (AD) is a skin disease also called eczema. It is common in children and sometimes gets better on its own. However, chronic AD may cause asthma, food allergies, eye infections, and sleep problems. The cause of AD might be related to bacteria that live on the skin. Researchers want to see if introducing bacteria, R mucosa, from healthy skin onto the skin of someone with AD helps treat the disease.
Objective:
To test the safety and activity of R mucosa for treating AD.
Eligibility:
Part 1: People ages 18 and older with AD
Part 2: Children ages 3-17 with AD
Design:
Participants will be screened with:
Medical history
Physical exam
Examination of their AD
Blood and urine tests
At the baseline visit, participants will have blood tests and photos taken of their skin. They will get a supply of R mucosa and a memory aid to track their doses and record how they are feeling. Part 2 participants guardians will complete questionnaires about their child s AD.
Part 1 participants will spray R mucosa on their arm twice per week for 6 weeks.
Part 2 guardians will spray it on their child s arm twice per week for 16 weeks.
Participants will have follow-up visits to repeat some baseline tests and review their memory aid:
Part 1: Six weeks after the baseline visit
Part 2: Four times over 16 weeks; then 2 or 3 times for 1 year
Participants will be called or emailed to discuss how they are feeling:
Part 1: About 30 days after their last visit
Part 2: About every 10 days between visits