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Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

NeoplasmsRespiratory Diseases

Active Indication-

Inactive Indication

Lung Cancer

Originator Organization

Wuhan University

Active Organization-

Inactive Organization

Wuhan University

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

A series of diamides derivatives containing nicotinamide unit were designed, synthesized and evaluated for their potential cytotoxic activities against human cancer cell lines. All the synthesized compounds were characterized using spectroscopic methods mainly including ¹H NMR, ¹³C NMR and MS. The bio-evaluation results indicated that some of the obtained compounds (such as 4d, 4h, 4i) exhibited good to moderate cytotoxic effects on lung cancer cell lines (NCI-H460, A549, and NCI-H1975), especially, compound 4d exhibited the highly potential inhibitory activities against NCI-H460 cell line with the IC₅₀ values of 4.07 ± 1.30 μg/mL, which might be developed as novel lead compounds for potential cytotoxic agents.

100 Deals associated with Compound 4d (Wuhan University)

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