Recently, concern on several environmental issues including the pollutant discharge and high concentration of CO₂ have gained high interest due to its impact on ecosystem and global warming effect, respectively. Implementation of photosynthetic microorganism carries out numerous advantages including high efficiency of CO₂ fixation, the great endurance under extreme conditions and generation of valuable bioproducts. Thermosynechococcus sp. CL-1 (TCL-1), a cyanobacterium, has the ability to perform CO₂ fixation and accumulation of various byproducts under extreme conditions like high temperature and alkalinity, presence of estrogen, or even using swine wastewater. This study aimed to assess TCL-1 performance under various endocrine disruptor compounds (bisphenol-A, 17-β-estradiol/E2, and 17-α-ethynilestradiol/EE2), concentrations (0-10 mg/L), light intensities (500-2000 µE/m²/s), and dissolved inorganic carbon/DIC levels (0-113.2 mM). Addition of E2 content even until 10 mg/L carried out insignificant biomass growth interruption along with the improvement in CO₂ fixation rate (79.8 ± 0.1 mg/L/h). Besides the influence of E2, application of higher DIC level and light intensity also enhanced the CO₂ fixation rate and biomass growth. The highest biodegradation of E2 at 71% was achieved by TCL-1 in the end of 12 h cultivation period. TCL-1 dominantly produced protein (46.7% ± 0.2%), however, production of lipid and carbohydrate (39.5 ± 1.5 and 23.3 ± 0.9%, respectively) also could be considered as the potential source for biofuel production. Thus, this study can provide an efficient strategy in simultaneously dealing with environmental issues with side advantage in production of macromolecules.

01 Sep 2021·Bioresource TechnologyQ1 · ENGINEERING & TECHNOLOGY

Nitrogen and 17β-Estradiol level regulate Thermosynechococcus sp. CL-1 carbon dioxide fixation, monosaccharide production, and estrogen degradation

Q1 · ENGINEERING & TECHNOLOGY

Article

Author: Chang, Jia-Yuan ; Hsueh, Hsin-Ta ; Narindri Rara Winayu, Birgitta ; Chu, Hsin

Thermosynechococcus sp. CL-1 (TCL-1), a thermophilic cyanobacterium from a hot spring in Taiwan, has been known of its efficiency in CO₂ fixation, byproducts production (pigments, macromolecules). This study observed the performance of TCL-1 in CO₂ fixation, estrogen degradation, and monosaccharide production under various levels of Dissolved Inorganic Nitrogen (DIN) and 17β-estradiol (E2) as nitrogen supply and estrogen addition. Under nitrogen starvation, TCL-1 performed similar results on CO₂ fixation rate and biomass production but enhanced the monosaccharide production compared to the cases of high nitrogen supply. The highest CO₂ fixation rate and glucose productivity reached to 151.8 ± 6.6 and 38.1 ± 0.9 mg/L/h, under DIN level of 0.58 mM and 0.5 mg/L E2. Adding E2 in the system did not inhibit the performance of TCL-1. During the cultivation, TCL-1 converted E2 into E1 and the biodegradation was the main path for estrogen degradation. Total E2 degradation reached to 69.4 ± 2.0%.

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Indication	Highest Phase	Country/Location	Organization	Date
Hematologic Neoplasms	Preclinical	US	Purdue University	15 Oct 2023

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