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Last update 08 May 2025

Isonixin

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Isonixin (INN), Nixyn hermes

Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System DiseasesOther Diseases

Active Indication

InflammationPain

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC14H14N2O2

InChIKeyWJDDCFNFNAHLAF-UHFFFAOYSA-N

CAS Registry57021-61-1

100 Clinical Results associated with Isonixin

100 Translational Medicine associated with Isonixin

100 Patents (Medical) associated with Isonixin

Literatures (Medical) associated with Isonixin

01 Jul 2020·Crystal Growth & Design

Steric Effect Determines the Formation of Lactam–Lactam Dimers or Amide C═O···NH (Lactam) Chain Motifs in N-Phenyl-2-hydroxynicotinanilides

Author: Li, T. ; Cao, S. ; Long, S. ; Yu, F. ; Zhang, M. ; Yang, Z. ; Parkin, S. ; Chen, J. ; Yang, X. ; Liu, H.

A series of N-phenyl-2-hydroxynicotinanilides (PHNAs) have been synthesized, and their crystal structures have been investigated.The identity of these compounds is revealed to be the tautomer of PHNAs, i.e., 2-oxo-1,2-dihydropyridine-3-carboxylic acid phenylamides, compounds with both amide and lactam functionalities.Among these compounds, those with no or negligible steric hindrance take a near planar conformation and form lactam-lactam dimers, not the widely observed amide NH···O=C hydrogen bond chains, while those with steric hindrance take a twisted conformation and form an amide NH···O=C (lactam) hydrogen bond.A succinct theoretic study combining conformational anal. and mol. electrostatic potential surfaces (MEPS) survey provided a reasonable explanation of the formation of these two different hydrogen bond motifs.The identity of N-phenyl-2-hydroxynicotinanilides is revealed to be their tautomers, 2-oxo-1,2-dihydropyridine-3-carboxylic acid phenylamides, compounds with both amide and lactam functionalities.The steric effect plays an important role in the formation of lactam-lactam dimers or amide-lactam catemer motifs in these compoundsTheor. studies have provided a reasonable explanation for the exptl. observations.

01 May 2015·European Journal of Organic Chemistry

One‐Pot Synthesis of N‐Aryl‐Nicotinamides and Diarylamines Based on a Tunable Smiles Rearrangement

Author: Shilei Zhang ; Shihui Liu ; Pengfei Qian ; Shaofan Zhu ; Yinan Zhang ; Linsen Shi ; Jiayu Gao ; Shaohua Chen ; Yanwei Hu ; Ying Wu

AbstractA one‐pot Smiles rearrangement has been developed as a useful protocol for the straightforward synthesis of diverse N‐aryl‐nicotinamides. This method also provides chemoselective access toward diarylamines based on the different substitutions of the amide group. The potential application of the transformation is exemplified by the synthesis of an on‐market succinate dehydrogenase inhibitor, boscalid.

01 Sep 2010·Chemical Biology & Drug Design

Exploring QSARs of Some Analgesic Compounds by PC‐ANN

Article

Author: Deeb, Omar ; Drabh, Mojahed

Quantitative structure–activity relationship study was performed to understand analgesic activity for a set of 95 heterogeneous analgesic compounds. This study was performed by using the principal component‐artificial neural network modeling method, with application of eigenvalue ranking factor selection procedure. The results obtained by principal component‐artificial neural network give advanced regression models with good prediction ability using a relatively low number of principal components. A 0.834 correlation coefficient was obtained using principal component‐artificial neural network with six extracted principal components.

100 Deals associated with Isonixin

External Link

KEGG	Wiki	ATC	Drug Bank
D08089	-	R03AB02	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Inflammation	-	-	-
Pain	-	-	-

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