Delving into the Latest Updates on Carbimazole with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Athyromazole, Carbethoxymethimazole, Carbimazole (INN)

+ [6]

Target

TPO

Mechanism

TPO inhibitors(Thyroid peroxidase inhibitors)

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

HyperthyroidismThyrotoxicosis

Inactive Indication-

Originator Organization

Tianjin Tianyao Pharmaceuticals Co., Ltd.

Active Organization

Amdipharm Mercury (Australia) Pty Ltd

Tianjin Tianyao Pharmaceuticals Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

AU (23 May 2012),

HyperthyroidismThyrotoxicosis

Regulation-

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Structure/Sequence

Molecular FormulaC7H10N2O2S

InChIKeyCFOYWRHIYXMDOT-UHFFFAOYSA-N

CAS Registry22232-54-8

To determine how thyroid status regulates the relationship between brown adipose tissue (BAT) volume/activity, white adipose tissue (WAT) partitioning and basal metabolic rate (BMR) in hyperthyroid patients transitioning to euthyroidism via antithyroid drugs.
To compare euthyroid outcomes (BAT, WAT, BMR, body composition, body weight and insulin resistance) achieved by hypothalamus-pituitary-thyroid (HPT) set point vs. normal ranges of plasma free thyroxine 4 (FT4) and throxine stimulating hormone (TSH).

Start Date13 Oct 2015

Sponsor / Collaborator

Agency for Science, Technology & Research

ACTRN12615000362594

/ SuspendedPhase 4

Comparing risk of relapse in Graves' disease patients treated with fixed-time carbimazole vs. treatment guided by TRAb titre

Start Date16 Jun 2015

Sponsor / Collaborator-

TCTR20170123003

/ CompletedNot ApplicableIIT

Effect of Adding Carbimazole to Levothyroxine on Outcome in Patients with Primary Hypothyroidism: A Preliminary Study

Start Date01 Jan 2015

Sponsor / Collaborator-

100 Clinical Results associated with Carbimazole

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100 Translational Medicine associated with Carbimazole

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100 Patents (Medical) associated with Carbimazole

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1,129

Literatures (Medical) associated with Carbimazole

31 Dec 2024·Annals of Medicine

A systematic review of the clinical characteristics and course of atrioventricular blocks in hyperthyroidism

Review

Author: Choudry, Hassan ; Tahir, Shuja ; Khan, Haseeb Ahmad ; Illigens, Ben ; Cerqueira, Tiago Lemos ; Khan, Adeel Ahmad ; Ata, Fateen

BACKGROUNDAtrioventricular block (AVB) is rare in hyperthyroidism (HTH). Little is known about the true prevalence, clinical course, optimal management, and outcomes of different types of AVBs in patients with HTH. To address these uncertainties, we aimed to conduct a systematic review by combining the available literature to provide more meaningful data regarding AVBs in HTH.METHODSWe systematically searched PubMed, Scopus, Embase, and Google Scholar for articles reporting patients who developed AVB in the context of HTH. Data were analysed in STATA 16. The main outcomes included types of AVB, frequency of pacemaker insertion, and resolution of AVB. The systematic review is registered with the International Prospective Register of Systematic Reviews (PROSPERO) with the identification number CRD42022335598.RESULTSA total of 56 studies (39 case reports, 12 case series, 3 conference abstracts, 1 retrospective study, and 1 prospective observational study) with 87 patients were included in the analysis, with a mean age of 39.1 ± 17.6 years. Females constituted 65.7% (n = 48) of the cohort. Complete heart block (CHB) was the most commonly reported AVB (N = 45, 51.7%), followed by first-degree AVB (16.1%) and second-degree AVB (14.9%). Overall, 21 patients underwent pacing. A permanent pacemaker was inserted in one patient with second-degree AVB and six patients with CHB. Mortality was reported in one patient with CHB. The clinical course and management of HTH and AVBs did not differ in patients with CHB or lower-degree blocks. Apart from lower rates of goitre and more use of carbimazole in those who underwent pacing, no differences were found when compared to the patients managed without pacing.CONCLUSIONCurrent data suggest that CHB is the most common type of AVB in patients with HTH. Most patients can be managed with anti-thyroid management alone. Additionally, whether pacemaker insertion alters the clinical outcomes needs further exploration.

01 Nov 2024·Ultrastructural Pathology

Efficacy of ozone versus mesenchymal stem cell-derived microvesicles in ameliorating testicular changes after hypothyroidism in adult albino rats: a histological and immunohistochemical study

Article

Author: Ibrahem, Nahla E. ; Shalabi, Salma S. ; Abd EL-Baset, Samia A. ; Gawish, Magdy F.

This study was performed to: detect the histological, immunohistochemical, and biochemical alterations that may occur in the testes of adult rats in induced hypothyroidism. And to investigate which one, ozone or MSCs-MVs have better therapeutic effect on testicular changes after hypothyroidism. Eighty-four male adult rats were separated into: control group, hypothyroidism group: rats will be given carbimazole for 30 days, ozone group: rats treated as hypothyroidism group then will be injected with ozone intraperitoneal for 7 days. MSC-MVs group: rats treated as hypothyroidism group then will be injected with a single intravenous dose MSC-MVs. Specimens of testes were handled for light, electron microscope, and immunohistochemical of vimentin and S100. Biochemical analysis for; MDA and TNFα; serum testosterone, TSH, T3, and T4 was done, also, sperm count and morphology assay. Morphometric and statistical analysis were performed. Hypothyroidism group showed disorganized seminiferous tubules. A noticeable gap was between the basement membrane and the germinal epithelium. Wide interstitium had congested vessels and acidophilic homogenous material. Vacuolated germinal epithelium and few germ cells had dark nuclei with noticeable separation of between the basement membrane and the germinal epithelium. Ozone and MSCs-MVs induced improvement in all the previous parameters and restoration of spermatogenesis. In Conclusion MSCs-MVs has better ameliorative effect than ozone on hypothyroidism-exposed testes.

01 Oct 2024·Praxis

[A rare side effect of antithyroid drug therapy].

Article

Author: Bilz, Stefan ; Büchel-Boekstegers, Armgard ; Cozzio, Antonio ; Koster, Markus ; Lieberherr, Sven

INTRODUCTIONWe report a case of Graves' disease in a patient who initially received carbimazole therapy, which was switched to propylthiouracil due to adverse effects. After 14 months of propylthiouracil therapy, the patient developed cutaneous ANCA-associated vasculitis. Prompt cessation of propylthiouracil and topical treatment led to complete resolution of the skin lesions.

100 Deals associated with Carbimazole

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External Link

KEGG	Wiki	ATC	Drug Bank
D07616	Carbimazole	H03BB01	DB00389

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Thyrotoxicosis	AU	Amdipharm Mercury (Australia) Pty Ltd	23 May 2012
Hyperthyroidism	CN	Tianjin Tianyao Pharmaceuticals Co., Ltd.	-

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ENDO2024	Not Applicable	TSH receptor antibodies (TRAb)	-	Lithium	pryqaoryme(zjcltzxqrh) = Carbimazole-induced agranulocytosis pwhbaqaxzv (zfvdonxacv ) View more	-	01 Jun 2024
				Carbimazole
ODP523 (ENDO2022)	Not Applicable	Thyroid Crisis CD52 \| thyroid peroxidase antibody	-	Alemtuzumab	wbuneiwjpy(clxplgfzok) = The patient was agitated qdhzpgmuxc (zsojexuyzv ) View more	-	01 Nov 2022
				Carbimazole
ESPE2021	Not Applicable	-	-	Methimazole or carbimazole	(lvrjfljhio) = ufkxumiysk mmivxmqhny (voqfabrmxa ) View more	-	22 Sep 2021
ENDO2021	Not Applicable	Hyperthyroidism FT4 \| TSH	9	Carbimazole (Hyperthyroidism patients before treatment)	iizsnmehpa(kdylucfmbg) = plasma kallikrein, protein glutamine gamma-glutamyl transferase, serpin B3 qqqtwzavzr (hhuyedkdqs ) View more	-	03 May 2021
				Hyperthyroidism patients after Carbimazole treatment