Delving into the Latest Updates on Urea-13C with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Diagnostic radiopharmaceuticals

Synonyms

(13C)urea, Carbon 13 urea, Carbon-13 urea

+ [14]

Target-

Action

enhancers

Mechanism

PET imaging(Positron-emission tomography enhancers)

Therapeutic Areas

Infectious Diseases

Active Indication

Helicobacter pylori infection

Inactive Indication-

Originator Organization

Otsuka America Pharmaceutical, Inc.

Active Organization

Medical Diagnostics Australia

Richen Europe S.r.l.

INFAI, Institut für biomedizinische Analytik & NMR-Imaging GmbH

+ [2]

Inactive Organization

DIAGNOSTICS AND DEVICES INC

Otsuka America Pharmaceutical, Inc.

License Organization-

Drug Highest PhaseApproved

First Approval Date

United States (17 Sep 1996),

Helicobacter pylori infection

Regulation-

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Structure/Sequence

Molecular FormulaCH4N2O

InChIKeyXSQUKJJJFZCRTK-OUBTZVSYSA-N

CAS Registry58069-82-2

The mass production of urea, the most widely used agricultural fertilizer, usually relies on energy- and carbon-intensive processes.The light-driven synthesis path has great potential for more sustainable techniques to produce urea from abundant naturally occurring resources, but this method suffers fromthe use of pure CO₂ and high-energy-driven forces (high temperature or UV light).Herein, we present a mild photocatalytic pathway for urea production from diverse nitrogenous species (such as NO₃^-, NH₃, and N₂) and diluted CO₂ using visible light.We designed a palladium (Pd)-doped Schottky heterojunction, composed of graphene and titanium dioxide, as an effective photocatalyst to achieve on-farm urea generation.With the injection of visible-light-generated hot electrons from graphene to TiO₂, the as-integrated Pd(I) centers with a special oxidation state of +1.36 in the TiO₂ lattice can initiate the universal reaction path of cascade reduction of NO₃^-/N₂ to NH₃ and resulting C-N coupling of CO₂ with as-formed or added NH₃ to transform diverse nitrogenous species and CO₂ into urea.The urea yield over the at.-Pd@TiO₂/Gr photocatalyst is 1.62 mmol g^-1 h^-1 under visible-light irradiation with an apparent quantum yield of 1.05% at 400 nm and 0.39% even at 700 nm.

01 Apr 2024·American Journal of Physiology-Endocrinology and Metabolism

Effects of exogenous lactate on lipid, protein, and glucose metabolism—a randomized crossover trial in healthy males

Article

Author: Søndergaard, Esben ; Berg-Hansen, Kristoffer ; Gopalasingam, Nigopan ; Pedersen, Mette G B ; Rittig, Nikolaj ; Møller, Niels ; Gormsen, Lars C ; Bangshaab, Maj

Lactate is a decisive intermediary metabolite, serving as an energy substrate and a signaling molecule. The present study examines the effects of lactate on substrate metabolism and insulin sensitivity in healthy males. Hyperlactatemia reduces lipolysis by 30% without affecting insulin sensitivity and glucose metabolism. In addition, hyperlactatemia increases whole body amino acid turnover rate.

01 Feb 2022·Journal of Aerosol Medicine and Pulmonary Drug Delivery

Feasibility and Initial Safety Evaluation of Inhaled ¹³C-Urea in Ambulatory Patients with Pneumonia

Letter

Author: Norii, Tatsuya ; Candelaria, Lionel ; Femling, Jon ; Laliberte, Rena ; Bussmann, Silas ; Patel, Shivan ; Kotulski, Jillian ; Moyer, Michele ; Taylor, Robert M. ; Parchim, Nicholas F. ; Nowak, Richard ; Baca, Justin T. ; Odeesho, Samantha

100 Deals associated with Urea-13C

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External Link

KEGG	Wiki	ATC	Drug Bank
-	-	A03AX	DB09510

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Helicobacter pylori infection	Norway	INFAI, Institut für biomedizinische Analytik & NMR-Imaging GmbH	14 Aug 1997
Helicobacter pylori infection	Liechtenstein	INFAI, Institut für biomedizinische Analytik & NMR-Imaging GmbH	14 Aug 1997
Helicobacter pylori infection	Iceland	INFAI, Institut für biomedizinische Analytik & NMR-Imaging GmbH	14 Aug 1997
Helicobacter pylori infection	European Union	INFAI, Institut für biomedizinische Analytik & NMR-Imaging GmbH	14 Aug 1997