[Translation] A single-center, randomized, double-blind, placebo-controlled, dose-escalation phase I clinical study to evaluate the safety, tolerability and pharmacokinetic characteristics of topical rhNGF eye drops in healthy Chinese subjects
评价在中国健康受试者中单次、多次局部给予 rhNGF 滴眼液后的局部(眼部)和全身系统安全性、耐受性。评价在中国健康受试者中单次、多次局部给予 rhNGF 滴眼液后的全身系统药代动力学特征。评价在中国健康受试者中单次、多次局部给予 rhNGF 滴眼液后的全身系统免疫原性。评价 rhNGF 滴眼液在中国健康受试者眼内单次给药后的局部药代动力学特征。
[Translation] To evaluate the local (ocular) and systemic safety and tolerability of rhNGF eye drops after single and multiple topical administrations in healthy Chinese subjects. To evaluate the systemic pharmacokinetic characteristics of rhNGF eye drops after single and multiple topical administrations in healthy Chinese subjects. To evaluate the systemic immunogenicity of rhNGF eye drops after single and multiple topical administrations in healthy Chinese subjects. To evaluate the local pharmacokinetic characteristics of rhNGF eye drops after a single intraocular administration in healthy Chinese subjects.