Delving into the Latest Updates on Org-30035 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication-

Inactive Indication

Behavioural disorders

Originator Organization

Merck Sharp & Dohme Corp.

Active Organization-

Inactive Organization

Merck Sharp & Dohme Corp.

License Organization-

Drug Highest PhaseDiscontinuedPreclinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC33H47N7O9S

InChIKeyPPHNGCFEVHDHFE-WKAQUBQDSA-N

CAS Registry92122-44-6

Sequence Code 432052678

Pharmaceutical development of peptide and protein drugs presents new problems in the area of stability assessment.Generally, these products require more anal. effort than more classic drugs; this may even dictate the speed of products require more anal. effort than more classic drugs; this may even dictate the speed of progress in certain development phases.As shown on the work on the hexapeptide Org 30035, a straight-forward strategy that has proven successful in this respect is discussed.Structures of all products present in relative quantities >0.5% were assigned.Hydrolysis was the main cause of degradationHowever, some unexpected oxidations also contributed significantly to the decomposition of the peptide.With regard to protein drugs, the initial phase of pharmaceutical development, the (pre) formulation studies, was studied..Although numerous covalent and non-covalent processes determine protein stability, it is proposed that in this phase only three protein characteristics need to be monitored, namely activity, size and charge.For the anal. of the latter two phys. parameters, simple and rapid electrophoretic techniques exist.By using these techniques together with activity-test sufficient information can be gathered in a rapid fashion which enables efficient evaluation and selection of test-formulations for further development.Examples are shown that were obtained during the development of a monoclonal antibody.

100 Deals associated with Org-30035

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