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Last update 08 May 2025

Gandouling Tablets

Last update 08 May 2025

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Translational Medicine

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Herbal medicine

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Clinical Trials associated with Gandouling Tablets

NCT05305872

/ RecruitingPhase 4IIT

The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

To evaluate the efficacy and safety of gandouling tablet in the treatment of clinical symptoms of Wilson's diasease.

Start Date01 Jan 2023

Sponsor / Collaborator

The First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

100 Clinical Results associated with Gandouling Tablets

100 Translational Medicine associated with Gandouling Tablets

100 Patents (Medical) associated with Gandouling Tablets

128

Literatures (Medical) associated with Gandouling Tablets

01 May 2025·International Journal of Biological Macromolecules

Enhancement of gluconolactone-induced soybean protein isolate gels by low concentrations of oxidized konjac glucomannan: Gel properties and microstructure

Article

Author: Liu, Xiong ; Zeng, Zhilong ; Li, Yijia ; Wang, Haoyuan ; Li, Yao ; Luo, Jing ; Qin, Xiaoli ; Guan, Hongmei

Gluconolactone (GDL) induces soybean protein isolate (SPI) gelation by gradually releasing H⁺, lowering the pH to promote protein aggregation. However, excessive GDL often lead to an undesirable acidic taste in food gels. This study evaluated the effects of oxidized konjac glucomannan (OKGM) and varying H⁺ release levels on SPI gel properties, aiming to enhance gel quality while reducing GDL dependency. Results demonstrated that OKGM significantly improved gel texture and viscoelasticity, with low concentrations (0.5-1.5%, w/v) promoting SPI aggregation and forming a denser, more elastic gel network. Notably, OKGM accelerated the gelation process, reducing the gelation time from 12.88 ± 0.14 to 11.26 ± 0.00 min, while also increasing gel strength and stability. Fourier transform infrared spectroscopy (FT-IR) and thermogravimetric analysis (TGA) revealed that OKGM interacted with SPI through Schiff-base reactions, enhancing thermal stability. However, at high OKGM concentrations (2.0-2.5%, w/v), thermodynamic incompatibility led to phase separation, increasing surface hydrophobicity and free sulfhydryl content, which disrupted gel uniformity. Overall, OKGM synergized with GDL to induce gelation, enabling a reduction in acid coagulant usage while enhancing gel quality. This study provides a novel approach to designing low-calorie, fiber-rich SPI gels, offering a promising alternative to traditional soy gels in the food industry.

01 May 2025·Biomaterials Advances

Porcine plasma protein cold-set hydrogel crosslinked by genipin and the immunomodulatory, proliferation promoting and scar-remodeling in wound healing

Article

Author: Wang, Xue ; Kang, Xu ; Ma, Zhuanzhuan ; Liu, Jinbiao ; Kang, Sini ; Li, Hanluo ; Yao, Chenguang ; Hu, Kanghong ; Wu, Meiling ; Wei, Yanhong ; Yuan, Jianglan ; Fan, Junwei

Addressing the critical need for biocompatible and multifunctional wound dressings for chronic and non-healing wounds, cold-set hydrogel using natural biomacromolecules are potential candidates. This study developed a novel cold-set hydrogel of porcine plasma protein (PPP) through genipin (GP) as crosslinker and glucono delta-lactone (GDL) as acidifier. GP promoted hardness, springiness, water holding capacity (WHC) and modulus in a dose-dependent manner in the presence of GDL, and significantly enhanced microstructural density, integrity and anti-degradation, critical as wound dressing, achieving the optimal performance at 0.15 % GP and 0.2 % GDL. Subsequently, biocompatibility assessments revealed that the optimum PPP gel was low cytotoxicity and could support cell migration and proliferation, reduce apoptosis with dose-effect relationship of the filler PPP. Meanwhile, in vivo skin wound healing model indicated the efficacy in accelerating wound healing, reducing inflammation, and promoting tissue remodeling without excessive scar formation. These effects are attributed to the ability of PPP in the hydrogel to modulate local inflammatory responses, enhance angiogenesis, and balance extracellular matrix remodeling processes. In conclusion, this pioneering work establishes PPP cold-set hydrogels as promising candidates for advanced wound care solutions, combining the benefits of natural protein-based biomaterials with innovative crosslinking strategies to meet urgent clinical needs in regenerative medicine.

01 May 2025·International Journal of Biological Macromolecules

Composite cold-set gels of kidney bean protein isolate and basil seed gum induced by glucono-δ-lactone and sodium citrate: Preparation, gel properties and protection on astaxanthin

Article

Author: Chen, Han-Qing ; Li-Sha, Yi-Jing ; Yang, Qin

In this study, kidney bean protein isolate (KPI) and basil seed gum (BSG) thermal aggregates were prepared to form cold-set gels (KB) by adding sodium citrate (SC) and glucono-δ-lactone (GDL). The structure and gel properties of the cold-set gels were investigated. Results showed that the gels added with SC had higher water holding capacity and lower gel strength than GDL-induced gels. While the cold-set gels induced by GDL with the addition of SC (KB-GDL/SC) possessed compact gel network with higher viscoelasticity. Compared with KPI cold-set gels, the KB cold-set gels exhibited higher gel strength and greater capacity to capture water due to the filling and cross-linking effect of BSG, and its high hydrophilicity and changes on the KPI molecular structures. Moreover, the KB-GDL/SC presented a lower syneresis rate of 28.2 % than other gels after freeze-thaw treatment. Meanwhile, KB-GDL/SC showed better protection on astaxanthin under ultraviolet light or during heat treatment. All the KB cold-set gels controlled the release of astaxanthin during simulated digestion. Particularly for KB-SC, the loaded astaxanthin had the highest bioaccesssbility (24.5 %) after in vitro digestion. This study may provide unique insights for development of novel cold-set gels and related functional foods.

100 Deals associated with Gandouling Tablets

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Gandouling Tablets

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