Last update 23 Jan 2025

pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)

Overview

Basic Info

Drug Type
Therapeutic vaccine, mRNA vaccine
Synonyms
RNA-LPs(University of Florida), pp65-shLAMP DC(University of Florida), pp65-shLAMP mRNA DCs(University of Florida)
Target-
Mechanism
Immunostimulants
Therapeutic Areas
NeoplasmsNervous System DiseasesOther Diseases
Active Indication
Glioblastoma MultiformeRecurrent Glioblastoma
Inactive Indication-
Originator Organization
University of FloridaUniversity of Florida
Active Organization
University of FloridaUniversity of FloridaNational Cancer InstituteNational Cancer Institute
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)
NCT06389591
/ RecruitingPhase 1IIT
A Phase I Study of RNA-Lipid Particle (RNA-LP) Vaccines for Recurrent Adult Glioblastoma (GBM)
NCT02465268
/ CompletedPhase 2IIT
ATTAC-II: A Phase II Randomized, Blinded, and Placebo-controlled Trial of CMV RNA-Pulsed Dendritic Cells With Tetanus-Diphtheria Toxoid Vaccine in Patients With Newly-Diagnosed Glioblastoma
100 Clinical Results associated with pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)
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100 Translational Medicine associated with pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)
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100 Patents (Medical) associated with pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)
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100 Deals associated with pp65 fl LAMP mRNA-LPs Vaccine(University of Florida)
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Glioblastoma MultiformePhase 2
US
University of FloridaUniversity of Florida
09 Aug 2016
Recurrent GlioblastomaPhase 1
US
National Cancer InstituteNational Cancer Institute
29 Oct 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT02465268 (ATTAC-II, CTgov)
Phase 2
Astrocytoma | Glioblastoma Multiforme | Glioblastoma | Glioma
175
GM-CSF
(Arm 1: pp65-shLAMP DC With GM-CSF and Td)
erifhyjbpk(yoyhcfulzw) = sxekgnydwg jwcpjrxnvr (jhpoxnceko, fvjpdhpiov - acluallfkm)
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-
14 Jan 2025
pp65-flLAMP DC
(Arm 2: pp65-flLAMP DC With GM-CSF and Td)
erifhyjbpk(yoyhcfulzw) = egpztgjrgz jwcpjrxnvr (jhpoxnceko, uxvbmdflgb - oomradckay)
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Approval

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Regulation

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