Delving into the Latest Updates on Sibutramine sulfate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Butramin

Target

DAT x NET x SERT

Action

inhibitors

Mechanism

Dopamine reuptake inhibitors, NET inhibitors(Norepinephrine transporter inhibitors), Serotonin reuptake inhibitors

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Obesity

Inactive Indication-

Originator Organization

KYUNG DONG PHARMACEUTICAL Co., Ltd

Active Organization

KYUNG DONG PHARMACEUTICAL Co., Ltd

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

South Korea (27 Feb 2008),

Obesity

Regulation-

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Structure/Sequence

Molecular FormulaC17H26ClN

InChIKeyUNAANXDKBXWMLN-UHFFFAOYSA-N

CAS Registry106650-56-0

Currently, there is concern about food products to which new psychoactive substances (NPS) have been added illegally. However, rapid, high-sensitivity, and high-throughput screening methods for such harmful substances have not been reported yet. In this study, a high-throughput non-targeted screening strategy was developed based on UHPLC-Q/Orbitrap. First, optimized pretreatment methods for typical high-risk matrices were established. Second, an accurate, efficient, and scalable high resolution mass spectrometry database containing 206 NPS and related compounds was constructed. The fragmentation pathways of three different types of fentanyl-related compounds were then systematically investigated to enhance compound identification. Additionally, a non-targeted screening strategy was developed using warning ions derived from 24 fentanyl-related compounds, streamlining the identification of NPS. This strategy was applied to 100 food samples with possible illegal additives and demonstrated its effectiveness. In summary, this study provides robust technical support for regulatory authorities in combating the illegal addition of food products.

01 Feb 2025·Talanta

Portable unibody semi-flow injection voltammetric sensor for on-site screening of illegal additive sibutramine in food supplements

Article

Author: Saisahas, Kasrin ; Limbut, Warakorn ; Soleh, Asamee ; Wangchuk, Sangay ; Samoson, Kritsada ; Promsuwan, Kiattisak ; Saichanapan, Jenjira

In this study, a simple, portable, unibody semi-flow injection system was coupled with a screen-printed electrode (SFI/SPE) for the on-site electrochemical screening of sibutramine (SBM) in food supplements. The SFI was fabricated by laser engraving acrylic plastic and was attached to a modified SPE with double-sided adhesive tape. The SPE was modified with a nanocomposite of nitrogen-doped graphene nanoflakes and carbon nanotubes synthesized using hydrothermal and ultrasonic methods. The morphological structure and electrochemical properties of the nanocomposite were thoroughly investigated. The portable SFI-SPE sensing system was designed to be interfaced with a smartphone. Sample solutions can be continuously injected into the sensing system using a plastic syringe and SBM is determined by square wave anodic stripping voltammetry, controlled by means of a smartphone. The developed sensing system displayed linear ranges from 0.010 to 10 μg mL⁻¹ and 10-60 μg mL⁻¹ with an LOD of 0.0035 μg mL⁻¹. The sensor delivered a response in a short time and demonstrated not only good reproducibility (RSDs ranging from 2.9 % to 4.9 % (n = 10)) and excellent resistance to interference but also high accuracy. The developed sensor was utilized for the screening and quantification of SBM in food supplements but the system could be used in a wider range of electrochemical (bio) sensor applications in the future.

01 Jan 2025·Talanta

Identification of fenfluramine adulteration in slimming foods using a highly sensitive immunoassay

Article

Author: Yu, Xiaoqin ; Li, Zhaodong ; Wang, Yu ; Raza, Sayed Haidar Abbas ; Huang, Xin-an ; Huang, Xin-An ; Abbas Raza, Sayed Haidar ; Chen, Jiahong ; Zhang, Shiwei ; Lei, Hongtao ; Qian, Zhenjie ; Liu, Zhiwei ; Chen, Yanhong ; Zhenjie, Qian ; Pan, Kangliang

Fenfluramine, an appetite suppressant used for weight loss, can cause significant harm if overdosed. The unauthorized addition of fenfluramine to slimming foods has raised concerns. Currently, no rapid screening method is available for the quick detection of fenfluramine in the field. This study proposes six new haptens with varying spacer arm lengths and hydrophobicity, promising to elicit antibodies capable of being highly specific and strongly binding to fenfluramine. The study found that highly hydrophobic haptens with long spacer arms favored the generation of highly sensitive antibodies. Key interaction forces for antibody recognition of fenfluramine were revealed by intrinsic molecular mechanisms. Based on the above results, monoclonal antibody for fenfluramine was prepared and an ultrasensitive icELISA method with heterologous coating strategies was developed in slimming foods. The IC₅₀ of the method was 6.25 ng/mL, the linear detection range was 0.47-83.51 ng/mL and the detection limit was 0.10 ng/mL. Recovery rates in tea bags, tablets, capsules, coffee, and beverages ranged from 96.56 % to 108.90 %. The method was successfully applied to blind samples, showing strong correlation with HPLC-MS/MS results. Thus, the developed method is suitable for identifying fenfluramine adulteration in slimming foods.

100 Deals associated with Sibutramine sulfate

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