Last update 21 Nov 2024

JTT-251

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
PDHK
Mechanism
PDHK inhibitors(Pyruvate dehydrogenase kinase inhibitors)
Therapeutic Areas
Respiratory DiseasesOther DiseasesEndocrinology and Metabolic Disease
Active Indication-
Inactive Indication
Diabetes Mellitus, Noninsulin-Dependent, 2Pulmonary Arterial Hypertension
Originator Organization
Japan Tobacco (Hong Kong) Ltd.
Active Organization-
Inactive Organization
Akros Pharma, Inc.
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Structure

Molecular FormulaC26H28F3N3O4
InChIKeyKNPYQCPWTWANOG-RUZDIDTESA-N
CAS Registry1627957-25-8
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Related

6
Clinical Trials associated with JTT-251
PER-053-18 / SuspendedPhase 2
A PHASE 2, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF JTT 251 ADMINISTERED FOR 24 WEEKS TO PARTICIPANTS WITH PULMONARY ARTERIAL HYPERTENSION (RELIEF–PAH)
NCT03789643 / WithdrawnPhase 2
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JTT-251 Administered for 24 Weeks to Participants With Pulmonary Arterial Hypertension (RELIEF-PAH)
EUCTR2017-005093-19-DK / Not yet recruitingPhase 2
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of JTT-251 Administered for 24 Weeks to Participants with Heart Failure with Reduced Ejection Fraction - BEAT-CHF
100 Clinical Results associated with JTT-251
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100 Translational Medicine associated with JTT-251
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100 Patents (Medical) associated with JTT-251
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100 Deals associated with JTT-251
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Pulmonary Arterial HypertensionPhase 2-
Akros Pharma, Inc.
01 Mar 2019
Diabetes Mellitus, Noninsulin-Dependent, 2Phase 2
US
Akros Pharma, Inc.
01 Mar 2014
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Clinical Result

Indication
Phase
Evaluation
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Approval

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Regulation

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