Last update 20 Aug 2025

Cenicriviroc mesylate/Tropifexor

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cenicriviroc/tropifexor, Tropifexor/Cenicriviroc, CVC/LJN452
+ [1]
Target
CCR2 x CCR5 x FXR
Action
antagonists, agonists
Mechanism
CCR2 antagonists(C-C chemokine receptor type 2 antagonists), CCR5 antagonists(C-C chemokine receptor type 5 antagonists), FXR agonists(Bile acid receptor FXR agonists)
Therapeutic Areas-
Active Indication-
Inactive Indication-
Originator Organization
Novartis Pharma AG
Active Organization-
Inactive Organization-
License Organization-
Drug Highest Phase-
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC42H56N4O7S2
InChIKeyIXPBPUPDRDCRSY-YLZLUMLXSA-N
CAS Registry497223-28-6
View All Structures (2)

Related

1
Clinical Trials associated with Cenicriviroc mesylate/Tropifexor
CTRI/2018/06/014509
/ CompletedPhase 2
A randomized, double-blind, placebo controlled, 3- part,adaptive design, multicenter study to assesssafety, tolerability and efficacy of tropifexor (LJN452) in patients withnon-alcoholic steatohepatitis (NASH) - NASH
100 Clinical Results associated with Cenicriviroc mesylate/Tropifexor
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100 Translational Medicine associated with Cenicriviroc mesylate/Tropifexor
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100 Patents (Medical) associated with Cenicriviroc mesylate/Tropifexor
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100 Deals associated with Cenicriviroc mesylate/Tropifexor
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R&D Status

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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Approval

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Regulation

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