The purpose of the study is to determine the effect of cellulose sulfate on the transmission of HIV to women via vaginal intercourse. The secondary objectives are the effect on the transmission of gonorrhea and chlamydia via the same route.
The study hypothesis is that there will be no effect.

Start Date01 Jul 2005

Sponsor / Collaborator

Contraception Research and Development

[+1]

NCT00255294

/ CompletedPhase 2IIT

Non-Comparative Contraceptive Effectiveness Trial of Cellulose Sulfate (CS) Gel

This study will evaluate the contraceptive effectiveness of cellulose sulfate vaginal gel in preventing pregnancy when used for 6 months.

Start Date01 Jan 2005

Sponsor / Collaborator

Contraception Research and Development

NCT00120770

/ TerminatedPhase 3IIT

Randomized Controlled Trial of Cellulose Sulfate Gel and HIV in Nigeria

This is a Phase 3, multi-center, randomized, placebo-controlled trial to determine the effectiveness and safety of the 6% cellulose sulfate (CS) vaginal gel for the prevention of HIV infection.

Start Date01 Nov 2004

Sponsor / Collaborator

FHI 360

[+2]

100 Clinical Results associated with Cellulose Sulfate

100 Translational Medicine associated with Cellulose Sulfate

100 Patents (Medical) associated with Cellulose Sulfate

Literatures (Medical) associated with Cellulose Sulfate

01 Sep 2024·iScience

Antithrombogenic polysaccharide coatings to improve hemocompatibility, protein-repellence, and endothelial cell response

Article

Author: Nagy, Bence M. ; Nagaraj, Chandran ; Steindorfer, Tobias ; Fischer, Roland C. ; Nagy, Bence M ; Heinze, Thomas ; Fischer, Roland C ; Bračič, Matej ; Lackner, Florian ; Olschewski, Andrea ; Plohl, Olivija ; Mohan, Tamilselvan ; Kleinschek, Karin Stana

Polyester biomaterials play a crucial in vascular surgery, but suffer from unspecific protein adsorption, thrombogenicity, and inadequate endothelial cell response, which limit their success. To address these issues, we investigated the functionalization of polyester biomaterials with antithrombogenic polysaccharide coatings. A two-step and water-based method was used to coat cationized polycaprolactone with different sulfated polysaccharides (SPS), which resulted in long-term stability, tunable morphology, roughness, film thickness, chemical compositions, zeta potential, and water content. The coatings significantly increased the anticoagulant activity and reduced the thrombogenicity of polycaprolactone, particularly with highly sulfated heparin and cellulose sulfate. Less SPS, such as chondroitin sulfate, fucoidan, and carrageenan, despite showing reduced anticoagulant activity, also exhibited lower fibrinogen adsorption. The adhesion and viability of human primary endothelial cells cultured on modified polycaprolactone correlated with the type and sulfate content of the coatings.

01 Aug 2023·Journal of Biomedical Materials Research Part A

Scaffolds containing GAG‐mimetic cellulose sulfate promote TGF‐β interaction and MSC Chondrogenesis over native GAGs

Article

Author: Arinzeh, Treena Livingston ; Sherman, Lauren ; Rameshwar, Pranela ; Menezes, Roseline

AbstractCartilage tissue engineering strategies seek to repair damaged tissue using approaches that include scaffolds containing components of the native extracellular matrix (ECM). Articular cartilage consists of glycosaminoglycans (GAGs) which are known to sequester growth factors. In order to more closely mimic the native ECM, this study evaluated the chondrogenic differentiation of mesenchymal stem cells (MSCs), a promising cell source for cartilage regeneration, on fibrous scaffolds that contained the GAG‐mimetic cellulose sulfate. The degree of sulfation was evaluated, examining partially sulfated cellulose (pSC) and fully sulfated cellulose (NaCS). Comparisons were made with scaffolds containing native GAGs (chondroitin sulfate A, chondroitin sulfate C and heparin). Transforming growth factor‐beta3 (TGF‐β3) sequestration, as measured by rate of association, was higher for sulfated cellulose‐containing scaffolds as compared to native GAGs. In addition, TGF‐β3 sequestration and retention over time was highest for NaCS‐containing scaffolds. Sulfated cellulose‐containing scaffolds loaded with TGF‐β3 showed enhanced chondrogenesis as indicated by a higher Collagen Type II:I ratio over native GAGs. NaCS‐containing scaffolds loaded with TGF‐β3 had the highest expression of chondrogenic markers and a reduction of hypertrophic markers in dynamic loading conditions, which more closely mimic in vivo conditions. Studies also demonstrated that TGF‐β3 mediated its effect through the Smad2/3 signaling pathway where the specificity of TGF‐β receptor (TGF‐ βRI)‐phosphorylated SMAD2/3 was verified with a receptor inhibitor. Therefore, studies demonstrate that scaffolds containing cellulose sulfate enhance TGF‐β3‐induced MSC chondrogenic differentiation and show promise for promoting cartilage tissue regeneration.

01 Nov 2020·Journal of Environmental ManagementQ2 · ENVIRONMENTAL SCIENCE & ECOLOGY

Efficient removal of hexavalent chromium from electroplating wastewater using polypyrrole coated on cellulose sulfate fibers

Q2 · ENVIRONMENTAL SCIENCE & ECOLOGY

Article

Author: Hosseinkhani, Alireza ; Baghdadi, Majid ; Forouzesh Rad, Bahar

In this study, cellulose sulfate was synthesized through sulfonation of cotton, and polypyrrole was coated on the surface of fibers. Then, the optimum ratio of pyrrole to cellulose sulfate was evaluated, and the physical, chemical, and morphological properties of the composite were assessed by using FESEM, EDS, FTIR, BET, and TGA analysis. Furthermore, adsorption of hexavalent chromium using the composite adsorbent was studied by the results of designed experiments with the Box-Behnken technique to assess the effect of pH, contact time, adsorbent dose and the initial concentration of hexavalent chromium and optimize the adsorption process. The removal percentage was 99.9% under the optimum conditions (adsorbent dose, 4 g L-1; initial concentration of Cr(VI), 200 mg L-1; pH value, 2; contact time, 200 min). The results of adsorption isotherms illustrated that the adsorption process followed Redlich-Peterson, Freundlich, Radke-Prausnitz, and UT models, and the calculated maximum adsorption capacity by the Langmuir model was 198 mg g-1. Based on the kinetic and thermodynamic studies, the adsorption process followed the intraparticle diffusion model and showed the endothermic and spontaneous adsorption with an increase in entropy on the adsorbent surface. The presence of copper, nickel and zinc cations had no adverse effect on the removal percentage of hexavalent chromium significantly. The adsorbent was reused successfully in four sequential treatments. Consequently, the synthesized adsorbent is efficient due to the high efficiency of hexavalent chromium removal percentage from electroplating effluent (99.87%).

News (Medical) associated with Cellulose Sulfate

19 Oct 2005

·www.biospace.com

Multi-Country Phase III Clinical Trials To Test Microbicides To Prevent HIV Infection

The CONRAD program of the Eastern Virginia Medical School today announced that it has received a $12M grant from the Bill & Melinda Gates Foundation, with $12 million in matching funds committed by the US Agency for International Development (USAID), for a total of $24M. This grant plus the USAID award will allow two multi-country Phase III clinical trials of a product to prevent the transmission of HIV/AIDS. The main goal of the project is to determine if a vaginal microbicide candidate is an effective and safe method for preventing HIV transmission. CONRAD plans to meet this goal by completing two Phase III HIV prevention trials with a gel consisting of 6% cellulose sulfate (CS), also known as Ushercell®, developed by CONRAD in collaboration with Polydex Pharmaceuticals Limited, a publicly quoted (POLXF, Nasdaq) Canadian company. One trial, implemented by CONRAD, will be conducted in India and four African countries. This trials will be funded equally by the Gates Foundation and USAID. The other trial, initiated in late 2004 in Nigeria in collaboration with Family Health International (FHI), is entirely supported by USAID.

Phase 3

100 Deals associated with Cellulose Sulfate

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Indication	Highest Phase	Country/Location	Organization	Date
Contraception	Phase 3	United States	Contraception Research and Development	01 Jan 2005
Chlamydia Infections	Phase 3	-	Polydex Pharmaceuticals Ltd.	-
Gonorrhea	Phase 3	-	Polydex Pharmaceuticals Ltd.	-
HIV Infections	Phase 3	-	Polydex Pharmaceuticals Ltd.	-

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