Chlortetracycline hydrochloride (CTC) is a broad-spectrum tetracycline antibiotic used to prevent or resist different bacterial infections. However, due to its poor aqueous stability and physicochemical instability, its clinical development is limited. To improve such properties, CTC complexation with β-cyclodextrin (β-CD) and 2-hydroxypropanol-β-cyclodextrin (HP-β-CD) was performed using different preparation techniques (Freeze drying and ball milling). Inclusion complexes were comprehensively characterized using different analytical techniques and showed different properties distinct to pure CTC. In the presence of both CDs, CTC solubility was significantly improved. After ratio optimization, the optimal molar ratio after freeze-drying was determined to be 1:5. Compared to pure CTC powder (4 mg/mL), the solubility of CTC/HP-β-CD improved approximately 9 times (36 mg/mL), and a new CTC injection was successfully prepared. The antibacterial activity (in vivo and in vitro) of the CTC/HP-β-CD injection was then examined in natural infection chickens. Pathological tissue images showed that a 20 mg/kg CTC/HP-β-CD dose increased antibacterial activity and therapeutic effects. Additionally, we determined five clinical strains and statistically verified that CTC/HP-β-CD exhibits stronger antibacterial activity compared to CTC and other tetracycline drugs, with the most significant effect observed against Pseudomonas aeruginosa (MIC value of 2 μg/mL). Thus, these findings suggest that CTC/HP-β-CD inclusion complexes could be promising for pharmaceutical development, warranting further clinical evaluation, as solubility was significantly increased, and enhanced antibacterial activity was recorded in vivo and in vitro.

01 Jul 2025·Water Research

Performance of ultrafiltration-ozonation for municipal wastewater reclamation under rainstorm conditions: Impacts of DOM surge on micropollutant removal and associated risks

Article

Author: Li, Wentao ; Hu, Jun ; Hu, Yue ; Qiang, Zhimin ; Li, Mengkai ; Ben, Weiwei ; Li, Yangang ; Zhang, Wenzhen

This study investigated the impacts of rainstorms on the performance of a combined ultrafiltration (UF)-ozonation (O₃) process for micropollutant removal and risk mitigation during municipal wastewater reclamation. Results reveal that the rainstorm triggered a substantial surge in dissolved organic matter (DOM) in secondary effluent, primarily composed of protein-like substances and terrestrial humus. Meanwhile, 12 commonly detected pharmaceuticals and personal care products (PPCPs) were found at concentrations slightly lower than in normal weather, ranging from 5.0 to 545.0 ng L^-1. Following the rainstorm, the overall removals of PPCPs spanned a wide range of 14.8 %-77.7 %, where a significantly lower retention of high molecular-weight pollutants (e.g., ≥ 400 Da) was observed for UF. For the ozonation unit, the removals remained comparable, while the relative contribution of radical oxidation increased. This shift was related to the enhanced generation of HO^• and/or other reactive species, driven by the enrichment of unsaturated proteins (originating from upstream sludge loss) as precursors. Higher concentrations of disinfection by-products (DBPs), reaching up to 1372.5 μg L^-1, were observed in chlorinated effluents after the rainstorm, ascribing to the elevated content of terrestrial humus persisting through the treatments. While the risks associated with PPCPs were negligible, the formed DBPs posed considerable risks to human health (with cancer risk at 10^-5) and aquatic ecosystem (with risk quotient up to 13.6), particularly post ozonation. These findings highlight the role of rainstorm-fueled DOM in reclaimed water quality and provide insights into ensuring reclaimed water safety under different weather conditions.

01 Jun 2025·Water Research

Realistic exposure scenarios in combined sewer overflows: how temporal resolution and selection of micropollutants impact risk assessment

Article

Author: Junghans, Marion ; Ort, Christoph ; Singer, Heinz ; Furrer, Viviane

Organic micropollutants in combined sewer overflows (CSOs) pose a potential risk to aquatic ecosystems. Previous studies mainly reported event mean concentrations (EMCs) and often focused on a small number of substances. This study presents realistic exposure scenarios using high-temporal resolution (10-minute) data from 24 events at two CSO sites. We analyzed 49 dissolved organic micropollutants for all events and 198 for four events, including pharmaceuticals, pesticides, and road-related compounds, of which we detected 83 substances at least once. From these, we assessed the mixed chemical risk by applying acute quality criteria and evaluated how the risk assessment outcome changes for two aspects: temporal resolution and selection of substances. Our results reveal that total risk quotients (RQ_tot) can vary greatly within CSO events, with 10-minute data capturing peak concentrations that are missed with EMCs. Using EMCs underestimates the maximum RQ_tot of an event by a median factor of 4.9, up to a maximum factor of 6.9. When comparing a selection of 20 substances from the Swiss Waters Protection Ordinance to a broader list of 49 substances commonly detected at CSOs and a comprehensive list of 198 substances, the estimated RQ_tot increases between 1.1 to 2.3-fold. RQ_tot values exceed the threshold of 1 in 75 % of the events, requiring further dilution in the receiving water body. All three pollutant classes (pharma, pesticide, road) drive the total risk, and no specific phase during overflow events consistently poses higher risk than other phases, which challenges the design of effective mitigation measures. Furthermore, the exposure scenarios presented here offer essential input for future ecotoxicological research as they reveal high short-term fluctuations in RQ_tot whose ecological significance is still largely unknown.

100 Deals associated with Azithromycin Lactobionate

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Indication	Country/Location	Organization	Date
Pelvic Inflammatory Disease	China	Harbin Pharmaceutical Group Co., Ltd.	01 Jan 2001
Pneumonia	China	Harbin Pharmaceutical Group Co., Ltd.	01 Jan 2001

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