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Last update 08 May 2025

Phacolysin

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Sodium 5,12-dihydroazapentacene disulfonate, Sodium dihydroazapentacene polysulfonate

Target-

Action-

Mechanism-

Therapeutic Areas

Eye Diseases

Active Indication

Cataract

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC18H12N4Na2O6S2

InChIKeyVEWTWCXUHBUOJF-UHFFFAOYSA-N

CAS Registry3863-80-7

100 Clinical Results associated with Phacolysin

100 Translational Medicine associated with Phacolysin

100 Patents (Medical) associated with Phacolysin

Literatures (Medical) associated with Phacolysin

01 Nov 2018·Pharmaceutical Chemistry Journal

Antioxidant and Antiradical Activity of Drugs Intended for Treating Ophthalmic Disorders

Author: A. I. Matern ; Ya. A. Okulova ; E. R. Gazizullina ; E. L. Gerasimova ; A. V. Ivanova ; V. L. Rusinov

Ten dosage forms intended for ophthalmic use with declared and potential antioxidant properties were investigated.Antioxidant activity was determined using potentiometry with potassium hexacyanoferrate (III) as the oxidant.Antiradical activity was studied using the stable radical 2,2-diphenyl-1-picrylhydrazyl.The reaction half-lives of the investigated dosage forms were determinedRatios of the exptl. antioxidant activity to the content of main active ingredient were assessed.

01 Dec 2015·Journal of Nanoparticle Research

Organic–inorganic hybrid nanocomposites based on chitosan derivatives and layered double hydroxides with intercalated phacolysin as ocular delivery system

Author: Feng Cao ; Huibo Chi ; Zhiguo Qin ; Jie Zhang

Abstract: This study was mainly aimed to evaluate the potential use of a novel ocular drug delivery system, organic-inorganic hybrid nanocomposites based on chitosan derivatives and layered double hydroxides (LDH).Organic polymers of chitosan-glutathione (CG) and pre-activated chitosan-glutathione (CG-2MNA) were successfully synthesized and characterized.LDH with intercalated phacolysin (PCL), including larger hexagonal LDH-PCL (Lh-LDH-PCL), larger spherical LDH-PCL (Ls-LDH-PCL), smaller hexagonal LDH-PCL (Sh-LDH-PCL), CG hybrid LDH-PCL (LDH-PCL-CG), and CG-2MNA hybrid LDH-PCL (LDH-PCL-CG-2MNA), were preparedThe nanocomposites with particle size of 107.2-274.9 nm were characterized by powder X-ray diffraction, Fourier transform IR, transmission electron micrographs, etc.In vivo precorneal retention studies showed that the detectable time of all nanocomposites was prolonged from 2 to 6 h in comparison to PCL saline.Accordingly, the AUC_0-6h values of Lh-LDH-PCL, Ls-LDH-PCL, Sh-LDH-PCL, LDH-PCL-CG, and LDH-PCL-CG-2MNA nanocomposites were increased by 2.27-, 2.08-, 3.08-, 4.67-, and 3.36-fold, resp.The Draize test and hematoxylin and eosin staining demonstrated that modified LDH had no eye irritation after single and repeated administration.These results indicated that chitosan derivatives-LDH hybrid nanocomposite dispersion could be a promising ocular drug delivery system to improve precorneal retention time of drugs.Graphical Abstract: Thiolated chitosan-LDH hybrid nanocomposite dispersion could be a promising ocular drug delivery system to improve precorneal retention time of drugs and may facilitate penetration of drugs into tissues of the eyes.

01 Jun 2014·Spectrochimica Acta Part A: Molecular and Biomolecular SpectroscopyQ2 · CHEMISTRY

Spectroscopic studies on the interaction of Phacolysin and bovine serum albumin

Q2 · CHEMISTRY

Article

Author: Yu, Xianyong ; Liu, Heting ; Yao, Qing ; Xie, Wenlin ; Liao, Zhixi

The interaction between Phacolysin (PCL) and bovine serum albumin (BSA) under imitated physiological conditions was investigated by spectroscopic (fluorescence, UV-Vis absorption and Circular dichroism) techniques. The experiments were conducted at different temperatures (294K, 302K, 306K and 310K) and the results showed that the PCL caused the fluorescence quenching of BSA through a static quenching procedure. The binding constant (Ka), binding sites (n) were obtained. The corresponding thermodynamic parameters (ΔH, ΔS and ΔG) of the interaction system were calculated at different temperatures. The results revealed that the binding process was spontaneous and the acting force between PCL and BSA were mainly hydrogen bonding and van der Waals forces. According to Förster non-radiation energy transfer theory, the binding distance between PCL and BSA was calculated to be 2.41nm. What is more, both synchronous fluorescence and Circular dichroism spectra confirmed the interaction, which indicated the conformational changes of BSA.

100 Deals associated with Phacolysin

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	-	DB15951

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Cataract	China	-	-

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