Delving into the Latest Updates on CMP-3 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

chitin microparticle vaccine adjuvant (CMP Therapeutics)

Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication-

Inactive Indication

Vaccination

Originator Organization

CMP Therapeutics Ltd.

Active Organization-

Inactive Organization

CMP Therapeutics Ltd.

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Conjugated microporous polymers (CMPs), featured by broad tunability in molecule design, structure and properties, have been widely used as photocatalysts for water splitting to produce hydrogen. However, the conventional donor-acceptor (D-A) binary CMPs have not achieved satisfactory performance so far. In this contribution, a series of D₁-D₂-A ternary CMPs are synthesized by the atom-economical direct CH arylation polymerization (DArP), wherein the dibenzo[b,d]thiophene-S,S-dioxide (BTDO), tetraphenylethylene (TPE) and 3,4-ethylenedioxythiophene (EDOT) units serve as the acceptor (A), donor D₁ and donor D₂, respectively. The structure-property correlations of the CMPs are systematically investigated by optical, electrochemical, water contact angle, and hydrogen production performance tests, revealing that the ternary D₁-D₂-A CMPs can maximize hydrophilicity and charge separation through the synergistic effect of BTDO, EDOT, and TPE building blocks. As a result, the ternary CMP-3 with an optimal D/A ratio achieves the highest photocatalytic hydrogen evolution rate up to 81.4 mmol g^-1 h^-1 without the aid of Pt co-catalyst, which has a 26-fold and 101-fold improvement compared to the pristine D₁-A and D₁-D₂ binary CMPs, respectively. Meanwhile, a high apparent quantum yield of 11.1 % at 500 nm is successfully achieved. Density functional theory calculation discloses that D₁-D₂-A ternary CMPs possess the desirable molecular geometry and superior charge separation. This work provides a new design and synthetic strategy for the high-performance CMP-based photocatalysts.

02 Jan 2025·ChemMedChem

LIN28‐Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs

Article

Author: Giannino, Nicole ; Wu, Peng ; Goebel, Georg L. ; Sievers, Sonja ; Jiang, Mao

AbstractThe probing of small molecules with heterocyclic scaffolds covering unexplored chemical space and the evaluation of their biological relevance are essential parts of forward chemical genetics approaches and for the development of potential small‐molecule therapeutics. In this study, we profiled sets of chromenopyrazoles (CMPs) and tetrahydroquinolines (THQs), originally developed to target the protein–RNA interaction of LIN28–let‐7, in a cell painting assay (CPA) measuring cellular morphological changes. Selected LIN28‐inactive CMPs and THQs induced cellular morphological changes to different extents. The most CPA‐active CMPs 2 and 3 exhibited high bio‐similarity with the LCH and BET clusters, while the most CPA‐active THQs 13 and 20 indicated a mechanism of action beyond the currently established biosimilarity clusters. Overall, this work demonstrated that CPA is useful in revealing “hidden” biological targets and mechanisms of action for biologically inactive small molecules, which are CMPs and THQs targeting the RNA‐binding protein LIN28 in this case, evaluated in target‐based strategies. When compared with annotated reference compounds, CMP 3 exhibited a high biosimilarity with the dual BRD7/9 degrading PROTAC VZ185, suggesting that CPA could potentially function as a new phenotypic approach to identify degrader molecules.

28 Oct 2023·Scientific reports

Exploring the promising application of Be₁₂O₁₂ nanocage for the abatement of paracetamol using DFT simulations.

Article

Author: Alasmari, Fawaz ; Ur Rehman, Munir ; Gul, Sana ; Alharbi, Metab ; Ali, Qaisar ; Kainat ; Khan, Momin ; AlAsmari, Abdullah F

The removal of paracetamol from water is of prime concern because of its toxic nature in aquatic environment. In the present research, a detailed DFT study is carried out to remove paracetamol drug from water with the help of Be₁₂O₁₂ to eliminate the related issues. Three different geometries (CMP-1, CMP-2, CMP-3,) are obtained with the highest adsorption energies value (E_ads) of - 31.2316 kcal/mol for CMP-3 without any prominent structural change. It is observed from the study that O atom from the carbonyl group (C=O) and H atom from O-H group successfully interact with O and Be atoms of the nanocage respectively. Natural bonding orbitals analysis reveals charge transfer to paracetamol drug from Be₁₂O₁₂ nanocage with maximum charge transfer of - 0.159 e for CMP-3 with bond angle of 1.65 Å confirming the stability of the CMP-3 among the optimized complexes. The quantum theory of atoms in molecule concludes that the interaction between paracetamol drug molecule and Be₁₂O₁₂ is purely closed-shell weak electrostatic in nature in CMP-1 and CMP-3 and shared interaction in CMP-2. The thermodynamics analysis witnesses that the process is exothermic and spontaneous. The regeneration study reveals the reversible nature of the adsorbent. The overall study presents Be₁₂O₁₂ nanocage as a potential adsorbent and may be used in future for the purification of water from a number of emerging pollutants.

100 Deals associated with CMP-3

Login to view more data